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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | SYNTHESIS, EVALUATION OF MUTUAL PRODRUG AND ANALYTICAL METHOD DEVELOPMENT FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND ACECLOFENAC |
| Authors Name: | Sheetal R Darade , Swati J Shinde , Archana V Rajdeo , Nisha S Mhaske |
| Download E-Certificate: | Download |
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IJNRD_210314
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| Published Paper Id: | IJNRD2312021 |
| Published In: | Volume 8 Issue 12, December-2023 |
| DOI: | |
| Abstract: | Aceclofenac and paracetamol have shown effective simultaneous separation using the RP-HPLC method. In order to develop the method, multiple preliminary trial runs were conducted on the pre-validated RP-HPLC system using varying mobile concentrations and solvents containing different ratios of methanol to phosphate buffer (85:15). Inertsil C18 (4.6 x 250mm, 5μm) was used for chromatographic separation. Prior to usage, the produced mobile phase was degassed using ultrasonication and filtered through a 0.45 μm membrane filter using a vacuum pump. The injection volume was 20 μl, the column temperature was ambient, the flow rate was 1.0 mL/min, and a UV detector was used for detection at 276 nm. Aceclofenac had a retention time of 5.768 minutes and paracetamol 3.719 minutes, respectively, were found. In present study, this simultaneous method was validated according to ICH guidelines Q2 (R1). The above developed method was validated by using validation parameters viz, linearity, accuracy, precision and robustness. Straight line calibration graph were obtained in the concentration range 200-1000 µg/ml and correlation coefficient (r 2) for proposed method was found to be 0.999 for Paracetamol and 50-250 µg/ml with r2 value of 0.9992 for Aceclofenac. Both, system as well as method precision showed the developed method is precise with respect to RSD, tailing factor, and number of theoretical plats were calculated for both solutions, all the results are within limits. |
| Keywords: | Paracetamol, Aceclofenac, RP-HPLC Method, Linearity, Accuracy. |
| Cite Article: | "SYNTHESIS, EVALUATION OF MUTUAL PRODRUG AND ANALYTICAL METHOD DEVELOPMENT FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND ACECLOFENAC", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 12, page no.a129-a152, December-2023, Available :http://www.ijnrd.org/papers/IJNRD2312021.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2312021 Registration ID: 210314 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: a129-a152 Country: Ahmednagar, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2312021 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2312021 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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