ADVANCED TECHNOLOGY IN WURSTER COATING

Registration ID: IJNRD_206369

Published ID: IJNRD2311373

DOI: Click Here to Get

SHRADHA SUNIL BHANGE , RIYA RAJKUMAR SARDA

Keywords: pelletization techniques, Wurster process, quality by design

Among the pelletization techniques available at present, the Wurster process is a production method of great interest as it offers various advantages in single equipment. Continuous process, less manual interruption and batch- to-batch reproducible assurance are some advantages of Wurster-based pellet coating. Many scientists have no clarity on “Is the process scalable?” due to ‘n’ the number of process variables involved. There are five sets of process variables affecting the quality of pellets - Equipment variables, Coating liquid preparation variables, preheating variables, spraying variables and drying variables involved in the Wurster-based coating process. Many of them have medium and high risk. The risk needs to be reduced by studying the variables at the lab level during development using the quality by design (QbD) approach and experimental design software. Wurster basted coating process scale up possible based on complete optimization of process variables, understanding of risk associated with variables and implementation of scale-up factor calculation provided by vendor. Lab scale and commercial scale Wurster should be linear and preferably of the same manufacturer is the key to the successful implementation of scale-up factor.

Published Paper   E-Certificate

SHRADHA SUNIL BHANGE & RIYA RAJKUMAR SARDA (November-2023). ADVANCED TECHNOLOGY IN WURSTER COATING . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), d658-d667. https://ijnrd.org/papers/IJNRD2311373.pdf

Volume 8 Issue 11, November-2023

Pages : d658-d667

Paper Reg. ID: IJNRD_206369

Published Paper Id: IJNRD2311373

Downloads: 000122004

Research Area: Pharmacy

Country: MEHKAR, MAHARASHTRA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2311373.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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