INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Among the pelletization techniques available at present, the Wurster process is a production method of great
interest as it offers various advantages in single equipment. Continuous process, less manual interruption and batch-
to-batch reproducible assurance are some advantages of Wurster-based pellet coating. Many scientists have no
clarity on “Is the process scalable?” due to ‘n’ the number of process variables involved. There are five sets of
process variables affecting the quality of pellets - Equipment variables, Coating liquid preparation variables,
preheating variables, spraying variables and drying variables involved in the Wurster-based coating process. Many of
them have medium and high risk. The risk needs to be reduced by studying the variables at the lab level during
development using the quality by design (QbD) approach and experimental design software. Wurster basted coating
process scale up possible based on complete optimization of process variables, understanding of risk associated with
variables and implementation of scale-up factor calculation provided by vendor. Lab scale and commercial scale
Wurster should be linear and preferably of the same manufacturer is the key to the successful implementation of
scale-up factor.
Keywords:
Keywords: pelletization techniques, Wurster process, quality by design
Cite Article:
"ADVANCED TECHNOLOGY IN WURSTER COATING ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.d658-d667, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311373.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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