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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Exploring the in-vitro models for Parkinson’s Disease: Differentiation and Limitations |
| Authors Name: | Apurva Chittoda , NIKHIL NARWARIA |
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| Author Reg. ID: |
IJNRD_209750
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| Published Paper Id: | IJNRD2311362 |
| Published In: | Volume 8 Issue 11, November-2023 |
| DOI: | |
| Abstract: | An extensive synopsis of the several in-vitro models used in Parkinson disease (PD) research is given in the summary. The main features of Parkinson's disease (PD) pathology are discussed, such as the degeneration of dopaminergic neurons in the substantia nigra, the role of basal ganglia in motor function, and the complexity of both motor and non-motor symptoms in PD. This paper examines in vitro models; it covers primary cultures, organotypic cultures, induced pluripotent stem cells (iPSCs), genetic models, neurotoxin-based models, and cell lines (such SH-SY5Y, LUHMES, PC12, MN9D, N27, and Neuro2a). It delves into the differentiation methods, advantages, limitations, and applications of each model. Notably, it discusses the potential of these models in mimicking PD pathology, their use in screening potential treatments, and their significance in elucidating molecular mechanisms underlying PD pathogenesis. The document also addresses limitations of these models, including challenges in replicating the complexity of the central nervous system and the difficulty in simulating early disease stages. Ultimately, the review underscores the importance of in-vitro models in studying PD pathophysiology while acknowledging that no single model fully encapsulates all aspects of the disease. It emphasizes the need for combined models and highlights recent advancements in technologies like iPSCs and organoids derived from PD patient cells, offering new avenues for investigating neurodegenerative diseases. |
| Keywords: | Parkinson's Disease, In-vitro models, Cell lines, |
| Cite Article: | "Exploring the in-vitro models for Parkinson’s Disease: Differentiation and Limitations", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.d567-d580, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311362.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2311362 Registration ID: 209750 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: d567-d580 Country: INDORE, MP, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2311362 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2311362 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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