Paper Title
Exploring the in-vitro models for Parkinson’s Disease: Differentiation and Limitations
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Registration ID: IJNRD_209750
Published ID: IJNRD2311362
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Keywords
Parkinson's Disease, In-vitro models, Cell lines,
Abstract
An extensive synopsis of the several in-vitro models used in Parkinson disease (PD) research is given in the summary. The main features of Parkinson's disease (PD) pathology are discussed, such as the degeneration of dopaminergic neurons in the substantia nigra, the role of basal ganglia in motor function, and the complexity of both motor and non-motor symptoms in PD. This paper examines in vitro models; it covers primary cultures, organotypic cultures, induced pluripotent stem cells (iPSCs), genetic models, neurotoxin-based models, and cell lines (such SH-SY5Y, LUHMES, PC12, MN9D, N27, and Neuro2a). It delves into the differentiation methods, advantages, limitations, and applications of each model. Notably, it discusses the potential of these models in mimicking PD pathology, their use in screening potential treatments, and their significance in elucidating molecular mechanisms underlying PD pathogenesis. The document also addresses limitations of these models, including challenges in replicating the complexity of the central nervous system and the difficulty in simulating early disease stages. Ultimately, the review underscores the importance of in-vitro models in studying PD pathophysiology while acknowledging that no single model fully encapsulates all aspects of the disease. It emphasizes the need for combined models and highlights recent advancements in technologies like iPSCs and organoids derived from PD patient cells, offering new avenues for investigating neurodegenerative diseases.
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How To Cite (APA)
Apurva Chittoda & NIKHIL NARWARIA (November-2023). Exploring the in-vitro models for Parkinson’s Disease: Differentiation and Limitations. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), d567-d580. https://ijnrd.org/papers/IJNRD2311362.pdf
Issue
Volume 8 Issue 11, November-2023
Pages : d567-d580
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Paper Reg. ID: IJNRD_209750
Published Paper Id: IJNRD2311362
Research Area: Engineering
Author Type: Indian Author
Country: INDORE, MP, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2311362.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311362
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