Exploring the in-vitro models for Parkinson’s Disease: Differentiation and Limitations

Registration ID: IJNRD_209750

Published ID: IJNRD2311362

DOI: Click Here to Get

Apurva Chittoda , NIKHIL NARWARIA

Parkinson's Disease, In-vitro models, Cell lines,

An extensive synopsis of the several in-vitro models used in Parkinson disease (PD) research is given in the summary. The main features of Parkinson's disease (PD) pathology are discussed, such as the degeneration of dopaminergic neurons in the substantia nigra, the role of basal ganglia in motor function, and the complexity of both motor and non-motor symptoms in PD. This paper examines in vitro models; it covers primary cultures, organotypic cultures, induced pluripotent stem cells (iPSCs), genetic models, neurotoxin-based models, and cell lines (such SH-SY5Y, LUHMES, PC12, MN9D, N27, and Neuro2a). It delves into the differentiation methods, advantages, limitations, and applications of each model. Notably, it discusses the potential of these models in mimicking PD pathology, their use in screening potential treatments, and their significance in elucidating molecular mechanisms underlying PD pathogenesis. The document also addresses limitations of these models, including challenges in replicating the complexity of the central nervous system and the difficulty in simulating early disease stages. Ultimately, the review underscores the importance of in-vitro models in studying PD pathophysiology while acknowledging that no single model fully encapsulates all aspects of the disease. It emphasizes the need for combined models and highlights recent advancements in technologies like iPSCs and organoids derived from PD patient cells, offering new avenues for investigating neurodegenerative diseases.

Published Paper   E-Certificate

Apurva Chittoda & NIKHIL NARWARIA (November-2023). Exploring the in-vitro models for Parkinson’s Disease: Differentiation and Limitations. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), d567-d580. https://ijnrd.org/papers/IJNRD2311362.pdf

Volume 8 Issue 11, November-2023

Pages : d567-d580

Paper Reg. ID: IJNRD_209750

Published Paper Id: IJNRD2311362

Downloads: 000121986

Research Area: Engineering

Country: INDORE, MP, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2311362.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311362

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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