Paper Title
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND ASPIRIN IN API AND MARKETED FORMULATION BY USING U.V-VISIBLE SPECTROSCOPY
Article Identifiers
Authors
D Snigdha , Tanzila Ayesha , Rumana Samreen , G Sanjeev , K Komala
Keywords
UV-Visible Spectrophotometric method, Atorvastatin, Aspirin, validatiоn, Limit of Detection, Limit of Quantification
Abstract
A specific, rapid and simple UV-Visible Spectrophotometric method with good sensitivity was developed and validated for the simultaneous estimation of atorvastatin and aspirin in standard solutions and tablets. The method employed solving of simultaneous equations based on the measurement of absorbance of two wavelengths, 295nm and 294nm for Atorvastatin and Aspirin, respectively. The calibration was linear for both the drugs in a concentration range of 10 to 80µg/ml and correlation coefficient provide the desired information on linearity. The results of analysis were validated statistically that included parameters such as Precision, LOD, LOQ, Recovery, Robustness & results were found in the acceptance criteria. It can be concluded from the results that present method for the simultaneous determination of atorvastatin and aspirin in tablets is specific, accurate, rapid and precise.
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How To Cite (APA)
D Snigdha, Tanzila Ayesha, Rumana Samreen, G Sanjeev, & K Komala (November-2023). ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND ASPIRIN IN API AND MARKETED FORMULATION BY USING U.V-VISIBLE SPECTROSCOPY. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), d296-d309. https://ijnrd.org/papers/IJNRD2311329.pdf
Issue
Volume 8 Issue 11, November-2023
Pages : d296-d309
Other Publication Details
Paper Reg. ID: IJNRD_208738
Published Paper Id: IJNRD2311329
Downloads: 000121990
Research Area: Pharmacy
Country: Hanumakonda, Telangana, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2311329.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311329
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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