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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Phenotypic resistance and cytochrome oxidase mutation in female Anopheles mosquitoes collected from Katakwi district-Uganda |
| Authors Name: | Mukasa Sadik , Lukyamuzi Fahad Hussein , Tumwesige Berenali , Wasswa Caleb |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_209103
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| Published Paper Id: | IJNRD2311280 |
| Published In: | Volume 8 Issue 11, November-2023 |
| DOI: | http://doi.one/10.1729/Journal.36932 |
| Abstract: | Background of the study: Malaria is a global public health problem that causes massive morbidity and mortality and poses a higher burden of disease. Globally, malaria has an estimated 219 million cases and 435,000 deaths. Malaria is caused by Plasmodium species which are transmitted by the female Anopheles mosquitoes. In an attempt to control the spread of mosquitoes, Uganda’s MoH recommends use of insecticides. The current study is aimed at determining the prevalence of insecticide resistance in Katakwi district mosquito populations. Methodology: A cross-sectional study was conducted between October and December 2021 in Katakwi district. The mosquito larvae were collected from different ponds of Katakwi district and the paper insecticide resistance assay was carried out on them, DNA was extracted from them using the simple chelex procedure. A real-time was then used directly on DNA obtained from mosquito sections to detect point mutations conferring resistance to insecticides. Results: Most (37.6%) mosquitoes’ species were Anopheles arabiensis and over (55.9%) insecticides were Permethrin. All (100.0%) mosquitoes were alive upon application of the different insecticides. 88.2% were wild and 11.8% were mutants. This study reports presence with over 11.8% prevalence of cytochrome oxidase mutations in female Anopheles mosquitoes; a 5.3% deviation from the assumed prevalence of 6.5%. Conclusions: These mutations may heighten the malaria burden incase these mosquitoes continue to reproduce and pass on the mutant gene to the offspring. Moreover, a high incidence of malaria infections poses a great health risk within healthcare and therefore these mutations should be given urgent attention. An. arabiensis has the highest frequency of mutations illustrating the necessity to develop effective vector control strategies against these mosquito species rather than using pyrethroids insecticides. |
| Keywords: | Knockdown resistance, phenotypic resistance, cytochrome oxidase, single nucleotide polymorphism |
| Cite Article: | "Phenotypic resistance and cytochrome oxidase mutation in female Anopheles mosquitoes collected from Katakwi district-Uganda", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.c652-c661, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311280.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2311280 Registration ID: 209103 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.36932 Page No: c652-c661 Country: Kampala, Central, Uganda Research Area: Biological Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2311280 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2311280 |
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ISSN: 2456-4184
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