MELATONIN: A NEW HORIZON FOR DIABETIC PATIENTS

Registration ID: IJNRD_209403

Published ID: IJNRD2311252

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Anuska Dutta

Melatonin, Type 2 Diabetes, Oxidative stress.

The global prevalence of Diabetes Mellitus (DM) is increasing in leaps and bounds. The international diabetes federation (IDF) has estimated 592 million people will suffer from DM by 2035. Hence, finding a novel bio molecule that can effectively aid diabetes management is vital, as other existing drugs have numerous side effects. Melatonin, a pineal hormone having anti-oxidative and anti-inflammatory properties, has been implicated in circadian dysrhythmia-linked DM. Reduced levels of melatonin and a functional link between melatonin and insulin are implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Additionally, genomic studies revealed that rare variants in melatonin receptor 1b (MTNR1B) are also associated with impaired glucose tolerance and increased risk of T2DM. Despite considerable advances in the past few years, obesity and T2DM remain two major challenges for public health systems globally. In the past 9 years, genome-wide association studies (GWAS) have established a major role for genetic variation within the MTNR1B locus in regulating fasting plasma levels of glucose and in affecting the risk of T2DM. Moreover, exogenous melatonin treatment in cell lines, rodent models and diabetic patients has shown a potent effect in alleviating diabetes and other related complications. This highlights the role of melatonin in glucose homeostasis. However, there are also contradictory reports on the effects of melatonin supplementation. Thus, it is essential to explore if melatonin can be taken from bench to bedside for diabetes management. This review summarizes the therapeutic potential of melatonin in various diabetic models and whether it can be considered a safe drug for managing diabetic complications and diabetic manifestations like oxidative stress, inflammation, endoplasmic reticulum stress, mitochondrial dysfunction, metabolic dysregulation etc. However, these studies did not solve the question of whether melatonin is beneficial or detrimental, an issue that will be discussed in the context of the peculiarities of the melatonergic system. Melatonin receptors might have therapeutic potential as they belong to the highly druggable G protein-coupled receptor super family. Clarifying the precise role of melatonin and its receptors on glucose homeostasis is urgent, as melatonin is widely used for other indications, either as a prescribed medication or as a supplement without medical prescription, in many countries in Europe and in the USA.

Published Paper   E-Certificate

Anuska Dutta (November-2023). MELATONIN: A NEW HORIZON FOR DIABETIC PATIENTS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), c405-c412. https://ijnrd.org/papers/IJNRD2311252.pdf

Volume 8 Issue 11, November-2023

Pages : c405-c412

Paper Reg. ID: IJNRD_209403

Published Paper Id: IJNRD2311252

Downloads: 000122254

Research Area: Life Sciences 

Author Type: Indian Author

Country: North 24 PGS, West Bengal , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2311252.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311252

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