Emerging developments in transdermal delivery via microneedles

Emerging developments in transdermal delivery via microneedles

Registration ID: IJNRD_209200

Published ID: IJNRD2311231

DOI: Click Here to Get

Dhruv Bhavsar

Transdermal, Microneedle, Protein, Peptide, nanoparticle, Hydrogel, cancer

The effectiveness of transdermal drug delivery has been limited due to the inability of most drugs to penetrate the skin at therapeutic rates. However, the use of micron-scale needles has been proposed as a solution to increase skin permeability and improve transdermal delivery, particularly for macromolecules. Microneedles have been fabricated with various sizes, shapes, and materials using microelectronics industry tools. Solid microneedles have been the focus of most drug delivery studies, as they have been shown to enhance skin permeability to a wide range of molecules and nanoparticles in vitro. In vivo studies have demonstrated successful delivery of oligonucleotides, insulin-induced reduction of blood glucose levels, and immune response induction from protein and DNA vaccines. Proteins and peptides have become a significant therapeutic modality for various diseases due to their high potency and specificity. However, their large molecular weight, poor stability, and conformational flexibility make them challenging to formulate and deliver. Injection is the primary route for clinical administration of protein and peptide drugs, but it often results in poor patient compliance. Microneedles offer a portable, minimally invasive solution that can overcome the skin barrier and create reversible microchannels for effective macromolecule permeation. This review highlights recent advances in microneedle-mediated transdermal delivery of protein and peptide drugs, with a focus on representative microneedle design and fabrication. The current application status of microneedle-mediated transdermal protein and peptide delivery, particularly in the fields of infectious disease, diabetes, cancer, and other disease therapies, is also summarized. Finally, the current status of clinical translation and future development perspectives are provided.

Published Paper   E-Certificate

"Emerging developments in transdermal delivery via microneedles", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 11, page no.c237-c255, November-2023, Available :https://ijnrd.org/papers/IJNRD2311231.pdf

Volume 8 Issue 11, November-2023

Pages : c237-c255

Paper Reg. ID: IJNRD_209200

Published Paper Id: IJNRD2311231

Downloads: 000121123

Research Area: Pharmacy

Country: GANDHINAGAR, Gujarat, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2311231.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311231

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

IJNRD is Scholarly open access journals, Peer-reviewed, and Refereed Journals, High Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool), Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) with Open-Access Publications.

INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

Indexing In Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar | AI-Powered Research Tool, Microsoft Academic, Academia.edu, arXiv.org, Research Gate, CiteSeerX, ResearcherID Thomson Reuters, Mendeley : reference manager, DocStoc, ISSUU, Scribd, and many more

How to submit the paper?

Important Dates for Current issue

Paper Submission Open For: August 2025

Current Issue: Volume 10 | Issue 8

Last Date for Paper Submission: Till 31-Aug-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: International Peer-reviewed, Refereed, and Open Access Journal.

Subject Category: Research Area