Paper Title
Formulation And Evaluation Of Osmotic Controlled Released Matrix Tablets Of Losartan Potassium.
Article Identifiers
Authors
Dipendra Regmi , H.S. Keerthy
Keywords
Osmotic, Losartan potassium, Controlled release, Osmogens, Direct compression technique, Angiotensin II, Hypertensive, Dip coating, Drilling.
Abstract
The oral controlled release formulation system shows a controlled drug release in pre- determined rate for a prolonged period of time, thereby ensuring sustained therapeutic action. Osmotic Controlled drug delivery systems are most promising strategy-based system for controlled drug delivery. The main intention of the present research was to formulate and evaluate the osmotic controlled release matrix tablet of Losartan potassium using different types of osmogens and control releasing polymer. Losartan Potassium is an Angiotensin II receptor (Type AT1) antagonist commonly used in hypertensive patients. The tablets (F1-F9) were formulated using different ratios of osmotic agents such as mannitol and lactose with the combination of control releasing polymer HPMCK15M and compressed by direct compression techniques. The FTIR spectra of pure drug with different polymers and osmogens showed no interaction. The developed powders were subjected for the pre-compression parameters and punched using single head rotatory compression machine. The tablets were formulated with the weight of 550 mg and were subjected for the post- compression evaluation. The matrix tablets were coated by dip coating method using the coating solution composed of cellulose acetate, PEG- 400 and Acetone as solvent. The coated tablets were also evaluated for different parameters. The coated tablets finally drilled by 0.25 mm needle on center of the one side of the tablet. The optimized formulation, showed the pre- compression and post- compression parameters with in standard limit and in- vitro drug release of optimized formulation was found to be 97.71 % at the end of 12 hours.
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How To Cite (APA)
Dipendra Regmi & H.S. Keerthy (November-2023). Formulation And Evaluation Of Osmotic Controlled Released Matrix Tablets Of Losartan Potassium.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), b641-b649. https://ijnrd.org/papers/IJNRD2311181.pdf
Issue
Volume 8 Issue 11, November-2023
Pages : b641-b649
Other Publication Details
Paper Reg. ID: IJNRD_208760
Published Paper Id: IJNRD2311181
Downloads: 000121992
Research Area: Pharmacy
Country: Syangja, Gandaki, Nepal
Published Paper PDF: https://ijnrd.org/papers/IJNRD2311181.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311181
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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