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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Formulation And Evaluation Of Osmotic Controlled Released Matrix Tablets Of Losartan Potassium. |
| Authors Name: | Dipendra Regmi , H.S. Keerthy |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_208760
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| Published Paper Id: | IJNRD2311181 |
| Published In: | Volume 8 Issue 11, November-2023 |
| DOI: | |
| Abstract: | The oral controlled release formulation system shows a controlled drug release in pre- determined rate for a prolonged period of time, thereby ensuring sustained therapeutic action. Osmotic Controlled drug delivery systems are most promising strategy-based system for controlled drug delivery. The main intention of the present research was to formulate and evaluate the osmotic controlled release matrix tablet of Losartan potassium using different types of osmogens and control releasing polymer. Losartan Potassium is an Angiotensin II receptor (Type AT1) antagonist commonly used in hypertensive patients. The tablets (F1-F9) were formulated using different ratios of osmotic agents such as mannitol and lactose with the combination of control releasing polymer HPMCK15M and compressed by direct compression techniques. The FTIR spectra of pure drug with different polymers and osmogens showed no interaction. The developed powders were subjected for the pre-compression parameters and punched using single head rotatory compression machine. The tablets were formulated with the weight of 550 mg and were subjected for the post- compression evaluation. The matrix tablets were coated by dip coating method using the coating solution composed of cellulose acetate, PEG- 400 and Acetone as solvent. The coated tablets were also evaluated for different parameters. The coated tablets finally drilled by 0.25 mm needle on center of the one side of the tablet. The optimized formulation, showed the pre- compression and post- compression parameters with in standard limit and in- vitro drug release of optimized formulation was found to be 97.71 % at the end of 12 hours. |
| Keywords: | Osmotic, Losartan potassium, Controlled release, Osmogens, Direct compression technique, Angiotensin II, Hypertensive, Dip coating, Drilling. |
| Cite Article: | "Formulation And Evaluation Of Osmotic Controlled Released Matrix Tablets Of Losartan Potassium.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.b641-b649, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311181.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2311181 Registration ID: 208760 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: b641-b649 Country: Syangja, Gandaki, Nepal Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2311181 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2311181 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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