EFFECTS OF ETHANOL LEAF EXTRACT OF VERNONIA AMYGDALINA D (BITTER LEAF) ON HAEMATOLOGY AND LIPID PROFILE OF APPARENTLY HEALTHY ALBINO RATS

EFFECTS OF ETHANOL LEAF EXTRACT OF VERNONIA AMYGDALINA D (BITTER LEAF) ON HAEMATOLOGY AND LIPID PROFILE OF APPARENTLY HEALTHY ALBINO RATS

Registration ID: IJNRD_208934

Published ID: IJNRD2311158

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Enemali, Michael Okey , Ibrahim, Zakariyau , Ogana, Joy , Nwefia, Wilson Ifeanacho , Abdullahi Halimatu Sadiya

Bioactive compounds, Bitter leaf, Haematological parameters, Lipid profile, Vernonia amygdalina Delile.

Abstract Bitter leaf (Vernonia amygdalina Delile), family Asteraceae or Compositae is a perennial shrub that is widely used locally in Nigeria for both therapeutic and nutritional purposes. This study was conducted to evaluate the phytochemical composition and the effect of ethanol leaf extract of the plant on haematological parameter and lipid profile of rat. Sixteen (16) albino wistar rats were randomly divided into four groups of 4 rats each. All groups were fed with growers mash. Groups 2, 3 and 4 further received daily oral doses of 200 mg, 300 mg and 400 mg per kg body weight of the extract, respectively. After 14 days of administration, the animals were sacrificed and blood was collected through orbital-plexus. The presence of alkaloids, tannins, phenolics, saponins, flavonoids, terpenoids, glycosides, carbohydrate and resins were detected with saponins as the most abundant while steroids was found to be absent. Results equally showed a non-significant (p>0.05) decrease at the highest concentration (400 mg/kg body weight) in PCV (27.2± 1.7), Hb (75.30 ± 1.10), RBC (0.52± 0.01) and PLT (142.50 ±1.30). However, WBC (8.58± 0.50), MCH (153.69±2.80), MCV (0.41±0.0) and MCHC (332.0±2.90) increase significantly (p<0.05) at 400mg/kg when compare to control (41.0±1.8), (135.80±2.50), (1.31±0.03), (303.80±5.10), (1.47±0.40), (102.99±1.40), (0.33± 0.30) and (315.80±1.70) respectively. Result also indicated a non-significant (p>0.05) decrease in the lipid profile of the test rats relative to control. It was therefore concluded that the bitter leaf extract is rich in bioactive compounds but negatively affect the haematological parameters at 400mg/kg body weight with no remarkable effect on the lipid profile at the administered doses within the period of the research.

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"EFFECTS OF ETHANOL LEAF EXTRACT OF VERNONIA AMYGDALINA D (BITTER LEAF) ON HAEMATOLOGY AND LIPID PROFILE OF APPARENTLY HEALTHY ALBINO RATS", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 11, page no.b453-b464, November-2023, Available :https://ijnrd.org/papers/IJNRD2311158.pdf

Volume 8 Issue 11, November-2023

Pages : b453-b464

Paper Reg. ID: IJNRD_208934

Published Paper Id: IJNRD2311158

Downloads: 000121219

Research Area: Life Sciences 

Country: Nnamdi Azikiwe University, Awka, Anambra, Nigeria

Published Paper PDF: https://ijnrd.org/papers/IJNRD2311158.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311158

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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