Paper Title
EFFECTS OF ETHANOL LEAF EXTRACT OF VERNONIA AMYGDALINA D (BITTER LEAF) ON HAEMATOLOGY AND LIPID PROFILE OF APPARENTLY HEALTHY ALBINO RATS
Article Identifiers
Authors
Enemali, Michael Okey , Ibrahim, Zakariyau , Ogana, Joy , Nwefia, Wilson Ifeanacho , Abdullahi Halimatu Sadiya
Keywords
Bioactive compounds, Bitter leaf, Haematological parameters, Lipid profile, Vernonia amygdalina Delile.
Abstract
Abstract Bitter leaf (Vernonia amygdalina Delile), family Asteraceae or Compositae is a perennial shrub that is widely used locally in Nigeria for both therapeutic and nutritional purposes. This study was conducted to evaluate the phytochemical composition and the effect of ethanol leaf extract of the plant on haematological parameter and lipid profile of rat. Sixteen (16) albino wistar rats were randomly divided into four groups of 4 rats each. All groups were fed with growers mash. Groups 2, 3 and 4 further received daily oral doses of 200 mg, 300 mg and 400 mg per kg body weight of the extract, respectively. After 14 days of administration, the animals were sacrificed and blood was collected through orbital-plexus. The presence of alkaloids, tannins, phenolics, saponins, flavonoids, terpenoids, glycosides, carbohydrate and resins were detected with saponins as the most abundant while steroids was found to be absent. Results equally showed a non-significant (p>0.05) decrease at the highest concentration (400 mg/kg body weight) in PCV (27.2± 1.7), Hb (75.30 ± 1.10), RBC (0.52± 0.01) and PLT (142.50 ±1.30). However, WBC (8.58± 0.50), MCH (153.69±2.80), MCV (0.41±0.0) and MCHC (332.0±2.90) increase significantly (p<0.05) at 400mg/kg when compare to control (41.0±1.8), (135.80±2.50), (1.31±0.03), (303.80±5.10), (1.47±0.40), (102.99±1.40), (0.33± 0.30) and (315.80±1.70) respectively. Result also indicated a non-significant (p>0.05) decrease in the lipid profile of the test rats relative to control. It was therefore concluded that the bitter leaf extract is rich in bioactive compounds but negatively affect the haematological parameters at 400mg/kg body weight with no remarkable effect on the lipid profile at the administered doses within the period of the research.
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How To Cite (APA)
Enemali, Michael Okey, Ibrahim, Zakariyau, Ogana, Joy, Nwefia, Wilson Ifeanacho, & Abdullahi Halimatu Sadiya (November-2023). EFFECTS OF ETHANOL LEAF EXTRACT OF VERNONIA AMYGDALINA D (BITTER LEAF) ON HAEMATOLOGY AND LIPID PROFILE OF APPARENTLY HEALTHY ALBINO RATS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), b453-b464. https://ijnrd.org/papers/IJNRD2311158.pdf
Issue
Volume 8 Issue 11, November-2023
Pages : b453-b464
Other Publication Details
Paper Reg. ID: IJNRD_208934
Published Paper Id: IJNRD2311158
Downloads: 000122008
Research Area: Life SciencesÂ
Country: Nnamdi Azikiwe University, Awka, Anambra, Nigeria
Published Paper PDF: https://ijnrd.org/papers/IJNRD2311158.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311158
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