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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Evaluation of diuretic activity of ethanolic extract of leaves of Nerium oleander Linn. albino rats |
| Authors Name: | Mr. Pratik Khandappa Kore , Dr. Arati Malpani , Mr. Laxman Iranna Nimbale |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_208373
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| Published Paper Id: | IJNRD2311088 |
| Published In: | Volume 8 Issue 11, November-2023 |
| DOI: | |
| Abstract: | Abstract Background and objectives: Diuretics are the drugs which cause increase in urinary output of electrolytes and water from kidneys. The net loss of sodium and water in the urine is due to one or more re-absorptive processes occurring at different segments of the nephron. The increase water loss is actually secondary to the increased excretion of sodium chloride. This is achieved either by directly acting on different segments of the nephron or by indirectly modifying the contents of the urinary filtrate. Materials and Methods: The leaves of Nerium oleander Linn. were air dried, powdered and the plant materials are extracted by soxhlet extraction method. The extracts are concentrated using rotary vacuum to get solid mass. The study was carried out by using saluretic method in rats. The diuretic activity of ethanolic extract of leaves of Nerium oleander was evaluated by various parameters such as saluretic activity, natriuretic activity and carbonic anhydrase inhibition (CAI). Result: The different doses of EENO treated group have shown a significant increase in saluretic activity when compared to the other groups and in CAI activity the extract of EENO didn’t shows any significant result. Conclusion: From this study, it is clear that EENO have significant saluretic activity in animal models. The extract is non-toxic even at relatively high concentrations. |
| Keywords: | Saluretic, CAI, Nerium oleander, Furosemide, Albino rats |
| Cite Article: | "Evaluation of diuretic activity of ethanolic extract of leaves of Nerium oleander Linn. albino rats", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.a802-a805, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311088.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2311088 Registration ID: 208373 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: a802-a805 Country: Solapur, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2311088 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2311088 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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