TO STUDY THE ANTIFUNGAL ACTIVITY OF ISAVUCONAZOLE

TO STUDY THE ANTIFUNGAL ACTIVITY OF ISAVUCONAZOLE

Registration ID: IJNRD_207797

Published ID: IJNRD2311036

DOI: Click Here to Get

Kranti Dipak Payghan , Miss.Kale Ishwari , Miss. Gunjawate Isha , Miss kolpe priti , Miss Jawale Jyoti

Isavuconazole, Invasive fungal infections,Antifungal,Triazoles.

A novel broad-spectrum triazole that is effective against molds, yeasts, and dimorphic fungi is called isavuconazole. In vitro, isavuconazole exhibits efficacy against the majority of medically significant fungus, such as species of Aspergillus, Candida, and Cryptococcus. This triazole has several benefits, such as an IV water-soluble formulation (which does not include cyclodextrin), good oral dosage form bioavailability, and consistent human pharmacokinetics. The US Food and Drug Administration has approved isavuconazole as a prodrug of isavuconazim, a more recent second-generation triazole antifungal. authorized for the management of invasive mucormycosis and aspergillosis. The activity spectrum of isavuconazole, is similar to the one of the polyene amphotericin B. However, because of these medications' inconsistent absorption, severe adverse effects, important drug interactions, and tendency toward bone resistance, their usage is frequently restricted. When treating invasive fungal infections, iavuconazole is a desirable alternative due to its outstanding pharmacokinetic qualities and safety.Their pharmacology, the field of chemistry, in vitro sensitivity, pharmacodynamics/pharmacokinetics, clinical efficacy, safety, tolerability, dosage, and administration are all summarized in this review.

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"TO STUDY THE ANTIFUNGAL ACTIVITY OF ISAVUCONAZOLE ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 11, page no.a323-a334, November-2023, Available :https://ijnrd.org/papers/IJNRD2311036.pdf

Volume 8 Issue 11, November-2023

Pages : a323-a334

Paper Reg. ID: IJNRD_207797

Published Paper Id: IJNRD2311036

Downloads: 000121104

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2311036.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311036

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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