Paper Title
TO STUDY THE ANTIFUNGAL ACTIVITY OF ISAVUCONAZOLE
Article Identifiers
Authors
Kranti Dipak Payghan , Miss.Kale Ishwari , Miss. Gunjawate Isha , Miss kolpe priti , Miss Jawale Jyoti
Keywords
Isavuconazole, Invasive fungal infections,Antifungal,Triazoles.
Abstract
A novel broad-spectrum triazole that is effective against molds, yeasts, and dimorphic fungi is called isavuconazole. In vitro, isavuconazole exhibits efficacy against the majority of medically significant fungus, such as species of Aspergillus, Candida, and Cryptococcus. This triazole has several benefits, such as an IV water-soluble formulation (which does not include cyclodextrin), good oral dosage form bioavailability, and consistent human pharmacokinetics. The US Food and Drug Administration has approved isavuconazole as a prodrug of isavuconazim, a more recent second-generation triazole antifungal. authorized for the management of invasive mucormycosis and aspergillosis. The activity spectrum of isavuconazole, is similar to the one of the polyene amphotericin B. However, because of these medications' inconsistent absorption, severe adverse effects, important drug interactions, and tendency toward bone resistance, their usage is frequently restricted. When treating invasive fungal infections, iavuconazole is a desirable alternative due to its outstanding pharmacokinetic qualities and safety.Their pharmacology, the field of chemistry, in vitro sensitivity, pharmacodynamics/pharmacokinetics, clinical efficacy, safety, tolerability, dosage, and administration are all summarized in this review.
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How To Cite (APA)
Kranti Dipak Payghan, Miss.Kale Ishwari, Miss. Gunjawate Isha, Miss kolpe priti, & Miss Jawale Jyoti (November-2023). TO STUDY THE ANTIFUNGAL ACTIVITY OF ISAVUCONAZOLE . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), a323-a334. https://ijnrd.org/papers/IJNRD2311036.pdf
Issue
Volume 8 Issue 11, November-2023
Pages : a323-a334
Other Publication Details
Paper Reg. ID: IJNRD_207797
Published Paper Id: IJNRD2311036
Downloads: 000121984
Research Area: Engineering
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2311036.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311036
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