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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Formulation, Development And Evaluation Of Bilayer Tablets Containing Esomeprazole And Amoxycillin |
| Authors Name: | Prashant G. Bhukan , Dr. Satyam Z. Chemate |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_208025
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| Published Paper Id: | IJNRD2311016 |
| Published In: | Volume 8 Issue 11, November-2023 |
| DOI: | |
| Abstract: | The objective of the work is the formulation, development and evaluation of bilayer tablets containing Esomeprazole and Amoxycillin. Esomeprazole in the immediate release layer and Amoxycillin in the sustained release layer, using Crosspovidone, Cross Carmellose sodium as a superdisintegartion for the immediate release layer and the hydrophilic HPMC K100, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Immediate and sustained release layer tablets were formulated by direct compression method. The bilayer tablets was evaluated for their Precompression parameters, physical characteristics like bulk density, tapped density, compressibility index, Hausner’s ratio, angle of repose and post compression parameters like hardness, friability, drug content, % drug release, thickness, disintegration time. The immediate release layer was 97.73±0.19% and 96.98±0.41 in 90min. and sustained release layer was 98.86 ±0.07% and 98.76 ±0.04% in 720min. |
| Keywords: | Esomeprazole, Amoxicillin, Bilayer tablet, Immediate release, Sustained release, Antiulcer, Helicobacter pylori. |
| Cite Article: | "Formulation, Development And Evaluation Of Bilayer Tablets Containing Esomeprazole And Amoxycillin", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 11, page no.a134-a150, November-2023, Available :http://www.ijnrd.org/papers/IJNRD2311016.pdf |
| Downloads: | 000118760 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2311016 Registration ID: 208025 Published In: Volume 8 Issue 11, November-2023 DOI (Digital Object Identifier): Page No: a134-a150 Country: Ahmednagar, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2311016 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2311016 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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