Paper Title
Formulation, Development And Evaluation Of Bilayer Tablets Containing Esomeprazole And Amoxycillin
Article Identifiers
Authors
Prashant G. Bhukan , Dr. Satyam Z. Chemate
Keywords
Esomeprazole, Amoxicillin, Bilayer tablet, Immediate release, Sustained release, Antiulcer, Helicobacter pylori.
Abstract
The objective of the work is the formulation, development and evaluation of bilayer tablets containing Esomeprazole and Amoxycillin. Esomeprazole in the immediate release layer and Amoxycillin in the sustained release layer, using Crosspovidone, Cross Carmellose sodium as a superdisintegartion for the immediate release layer and the hydrophilic HPMC K100, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Immediate and sustained release layer tablets were formulated by direct compression method. The bilayer tablets was evaluated for their Precompression parameters, physical characteristics like bulk density, tapped density, compressibility index, Hausner’s ratio, angle of repose and post compression parameters like hardness, friability, drug content, % drug release, thickness, disintegration time. The immediate release layer was 97.73±0.19% and 96.98±0.41 in 90min. and sustained release layer was 98.86 ±0.07% and 98.76 ±0.04% in 720min.
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How To Cite (APA)
Prashant G. Bhukan & Dr. Satyam Z. Chemate (November-2023). Formulation, Development And Evaluation Of Bilayer Tablets Containing Esomeprazole And Amoxycillin. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(11), a134-a150. https://ijnrd.org/papers/IJNRD2311016.pdf
Issue
Volume 8 Issue 11, November-2023
Pages : a134-a150
Other Publication Details
Paper Reg. ID: IJNRD_208025
Published Paper Id: IJNRD2311016
Downloads: 000121979
Research Area: Pharmacy
Country: Ahmednagar, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2311016.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2311016
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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