Evaluation of anti-ulcer activity of ethanol extract of bark of ficus arnottiana (miq.) in albino rats.

Registration ID: IJNRD_207924

Published ID: IJNRD2310411

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Nimbale Laxman Iranna

Ficus arnottiana (Miq.), Moraceae, Ethanol, Pylorus ligation, ulcer index, sterols

Background and objectives: Ulcer is a GI disorder resulting due to mucosa membrane breach of the alimentary tract, which passes through the muscularis mucosa into the sub-mucosa to cause deeper peptic ulcer disease. It occurs due to imbalance between the aggressive and the defensive factors. Ficus arnottiana (Miq.) (Moraceae) is one of the medicinal plants which have anti ulcer property. Hence evaluate the anti ulcer activity of ethanol extract of ficus Arnottiana (Miq.) barks in albino rats. Materials and Methods: The barks of Ficus Arnottiana (Miq.) were air dried and powdered. The plant materials are extracted by maceration with ethanol for 72 hrs. The extracts are concentrated using rotary vacuum to get solid mass. The study was carried out by using pylorus ligation in-vivo screening method in albino rats. The animals are divided into 4 groups namely control group, standard group, low dose and high dose of EEFA treated group. The parameters are evaluated such as ulcer index, % protection and gastric volume, pH of gastric juices, total acidity. Result: The different doses of EEFA treated group have shown a significant decrease in ulcer index, gastric volume, pH, etc. when compared to the other groups. Conclusion: From this study, it is clear that Ficus Arnottiana (Miq.) bark extract have significant anti ulcer activity in animal models. The extract is non-toxic even at relatively high concentrations. The anti ulcer activity is probably due to the presence of sterols.

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Nimbale Laxman Iranna (October-2023). Evaluation of anti-ulcer activity of ethanol extract of bark of ficus arnottiana (miq.) in albino rats.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), e88-e91. https://ijnrd.org/papers/IJNRD2310411.pdf

Volume 8 Issue 10, October-2023

Pages : e88-e91

Paper Reg. ID: IJNRD_207924

Published Paper Id: IJNRD2310411

Downloads: 000122254

Research Area: Pharmacy

Author Type: Indian Author

Country: Solapur, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310411.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310411

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