Paper Title
FORMULATION AND EVALUATION OF BILAYER ANTI DIABETIC TABLETS
Article Identifiers
: Keywords
Glimeperide, Bilayer tablet, Xanthan gum, Magnesium Stearate Crospovidone, crosscarmellose sodium, microcrystalline cellulose
Abstract
Bilayer tablets of an Glimepiride hydrochloride is to formulate, and evaluate for oral sustained drug release, in pharmaceutical system to enhance its oral bioavailability, Reduction in drug toxicity, Reduction in dosing frequency of drug. Biphasic release is characterized by rapid initial release of the drug, followed by sustained rate of release. The drug released by the initial pulse, quickly attains the therapeutic plasma drug levels and ameliorates the slow onset of action of sustained release layer. This increases patient compliance as the patient is quickly relief. Such type of drug delivery systems is designed to deliver the drug in such a way that the drug level is maintained within the therapeutic window for a period as long as the system continues to deliver the drug and to avoid fluctuations in plasma drug level. The purpose of the research work was formulation development and evaluation bi-layer floating tablets of glimepiride to improve the oral therapeutic efficacy of these drugs exhibit pH dependent solubility and show good permeability from stomach and upper part of the small intestine into systemic circulation. Direct compression method form glimepiride was used to formulate bi-layer floating tablets.
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How To Cite (APA)
Sandesh Kumar, Yograj Mahajan, Vishal Gupta, Harish kumar Singh , & Kumar Abhishek (October-2023). FORMULATION AND EVALUATION OF BILAYER ANTI DIABETIC TABLETS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), d522-d538. https://ijnrd.org/papers/IJNRD2310371.pdf
Issue
Volume 8 Issue 10, October-2023
Pages : d522-d538
Other Publication Details
Paper Reg. ID: IJNRD_207785
Published Paper Id: IJNRD2310371
Downloads: 000121998
Research Area: Engineering
Author Type: Indian Author
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2310371.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310371
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