ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY (UPLC): A NOVEL APPROACH IN ANALYSIS OF PHARMACEUTICALS

ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY (UPLC): A NOVEL APPROACH IN ANALYSIS OF PHARMACEUTICALS

Registration ID: IJNRD_207791

Published ID: IJNRD2310328

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Omkar G. Tekale , Dr. Amol N. Khedkar , Vitthal B. Kaulage

Ultra Performance Liquid Chromatography, Higher Resolution, Higher Efficiency

A contemporary method called UPLC offers liquid chromatography a new path. Three aspects of liquid chromatography are enhanced by UPLC: sensitivity, resolution, and speed. A bridged ethylsiloxane/silica hybrid (BEH) structure column with fine particle size (less than 1.7μm) is used in this system. Pharmaceutical companies and analytical labs are currently looking for innovative ways to decrease the time and expense of drug analysis while enhancing product quality. Better resolution, assay sensitivity, and high sample throughput of UPLC provide cost-effective advantages over HPLC analysis and enable the performance of more analyses in less time. The UPLC separation procedure uses high pressure (up to 100 MPa). In addition, compared to traditional HPLC, it uses less reagent and has a shorter run time. The current review paper discusses the differences between HPLC and UPLC, validation of analytical methods, applications, and benefits and drawbacks of each.

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"ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY (UPLC): A NOVEL APPROACH IN ANALYSIS OF PHARMACEUTICALS ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 10, page no.d279-d292, October-2023, Available :https://ijnrd.org/papers/IJNRD2310328.pdf

Volume 8 Issue 10, October-2023

Pages : d279-d292

Paper Reg. ID: IJNRD_207791

Published Paper Id: IJNRD2310328

Downloads: 000121218

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310328.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310328

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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