NIOSOMES: REVOLUTIONIZING THE FIELD OF TARGETED DRUG DELIVERY SYSTEM

Registration ID: IJNRD_207582

Published ID: IJNRD2310290

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Dhruv Bhavsar

Niosomes, Compositions, Methods of Preparation, Encapsulation, Surfactants, Vesicles and Applications.

The rise of nanotechnology has sparked a surge in interest in nanocarriers as an efficient and safe means of delivering drugs. The challenge of achieving efficient and safe drug delivery has long been a concern in the field of medicine. Drug targeting, a mechanism by which drugs are administered in a manner that allows them to interact with specific tissues at a cellular or subcellular level, has emerged as a solution to this challenge. By utilizing modern techniques such as niosomes, drug targeting can be achieved. The use of nanotechnology, particularly the development of nanocarriers for drug delivery, has garnered significant attention due to the potential for these carriers to act as "magic bullets," selectively targeting affected organs and cells while leaving normal tissues unharmed. In recent decades, the formulation of surfactant vesicles has become an increasingly popular tool for improving drug delivery, capturing the interest of scientists in the field of drug delivery systems. Niosomes are molecular clusters that form through the self-association of non-ionic surfactants in an aqueous phase. These unique structures present an innovative and effective drug delivery system known as the novel drug delivery system (NDDS). One of the key advantages of niosomes is their ability to load both hydrophilic and lipophilic drugs. Niosomes are vesicular nano-carriers that are self-assembled through the hydration of non-ionic surfactants, cholesterol, or other amphiphilic molecules. They serve as a versatile drug delivery system with a wide range of applications, including dermal delivery and brain-targeted delivery. Compared to liposomes, niosomes offer several advantages. They are composed of biodegradable and relatively nontoxic non-ionic surfactants, making them a safer option. Additionally, niosomes are more stable and less expensive, providing a cost-effective alternative. This review aims to provide a comprehensive summary of the current research on niosomes. It offers a detailed overview of the formulation components, different types of niosomes, and the effects of these components on the formation of niosomes. The review also covers the fabrication and purification methods, as well as the physical characterization techniques used for niosomes. Furthermore, the review explores the recent applications of niosomes in the pharmaceutical field, including oral, ocular, topical, pulmonary, parental, and transmucosal drug delivery. It also discusses the potential cosmetic applications of niosomes. Finally, the review addresses the limitations of this drug delivery system and provides insights into the future outlook for niosomes.

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Dhruv Bhavsar (October-2023). NIOSOMES: REVOLUTIONIZING THE FIELD OF TARGETED DRUG DELIVERY SYSTEM. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), c829-c860. https://ijnrd.org/papers/IJNRD2310290.pdf

Volume 8 Issue 10, October-2023

Pages : c829-c860

Paper Reg. ID: IJNRD_207582

Published Paper Id: IJNRD2310290

Research Area: Pharmacy

Author Type: Indian Author

Country: GANDHINAGAR, Gujarat, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310290.pdf

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