CEFTRIXONE SERIOUS INFECTION DISEASE IN SEPTICEMIA

Registration ID: IJNRD_207080

Published ID: IJNRD2310272

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Sakshi Kadam, Khopade Abhijit, Udamale Nikhil

: Ceftriaxone; Dose; Pharmacokinetics; Sepsis SEPSIS EPIDOMILOGY; INFECTION SITE; PATHOGEN;

Abstract Ceftriaxone belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. It is generally recognized as safe and effective when used as a single drug in the therapy of septicemia and other serious infections involving bacteremia in both adults and children. An advantage of ceftriaxone over other third-generation cephalosporins is its long serum half-life, which allows the drug to be given every 12 hours in children or less frequently in adults also Two potent third generation cephalosporins with similar antibacterial spectra, but different pharmacokinetics were compared in patients suffering from septicemia due to different organisms Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection, associated with a mortality rate over 25%, that has been designated a global health priority. Most of the sepsis is community-acquired, and progression can be insidious, making diagnosis difficult. Prognosis depends on early administration of broad-spectrum antibiotics and effective source control. Certain factors which are major determinants in the survival of the septic patient - age, underlying disease, infecting organism - are beyond the physician's control. Others, however, we can have some impact on. These include initial vigorous supportive treatment, early and appropriate antibiotic administration and timely surgical intervention. In the following discussion current understanding of the pathophysiology of sepsis is outlined, together with a practical approach to the problem of patient management. Risk factors for the development of septicemia, which are similar to those associated with any urinary tract infection, are reviewed. The "ABCs of Management" are outlined. Early recognition and effective management including selection of an effective antimicrobial agent for empiric therapy can have a direct impact on the patient's survival. Potential infecting type of bacteria are reviewed, and specific empiric therapies are described. In addition to antibiotic administration, rapid resuscitation and surgical drainage or debridement of the source of infection are integral parts of immediate treatment for sepsis. The importance of locating and draining (or removing) the source of infection is emphasized. Since sepsis is a systemic infection, patients must be monitored closely for failure of vital physiologic functions. Suggestions are offered for dealing with lack of response to antibiotic and supportive measures. Rapid diagnosis and effective management can improve the prognosis for septic patients. Ceftriaxone sodium MW: 552.600 g/mol MF: C18H16N8O7S3-2 IUPAC name: (7R)-7-[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoace.

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Sakshi Kadam, Khopade Abhijit, & Udamale Nikhil (October-2023). CEFTRIXONE SERIOUS INFECTION DISEASE IN SEPTICEMIA. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), c651-c657. https://ijnrd.org/papers/IJNRD2310272.pdf

Volume 8 Issue 10, October-2023

Pages : c651-c657

Paper Reg. ID: IJNRD_207080

Published Paper Id: IJNRD2310272

Research Area: Pharmacy

Author Type: Indian Author

Country: SOLAPUR, MAHARASHTRA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310272.pdf

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