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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | FORMULATION AND DEVELOPMENT OF CIPROFLOXACIN,MICONAZOLE,AND FLUOCINOLONE ACETONIDE LOADED NANOPARTICLE AND ITS EVALUATION |
| Authors Name: | ANUPAM ANAND , DR.SURESH CHAUDHARY |
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IJNRD_207249
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| Published Paper Id: | IJNRD2310242 |
| Published In: | Volume 8 Issue 10, October-2023 |
| DOI: | |
| Abstract: | In the present study, we have developed and characterized Ciprofloxacin, Miconazole, and Fluocinolone Acetonide simultaneously loaded PLGA nanoparticles to enhance the bioavailability of both the agents, to achieve the therapeutic advantage of the combination and to obtain sustained release of the drug. These nanoparticles have been characterized for their size, morphology, drug loading, and entrapment efficiency and optimized at different theoretical drug loadings and also evaluated in vitro to see their release from the formulation. Nanoparticles were prepared by emulsion-diffusion-evaporation method using PLGA (75/25) at three different drug loadings 5%, 10%, and 15%. The % entrapment efficiency was found to increase with the increase in drug loading from (5% to 15%). The % yield was found to increase from 58% to 80%. The particle size of nanoparticles was found to be 222-283 nm with a polydispersity index below 0.312 and a zeta potential of around -6.0 mV was observed. D- trehalose (10% w/v) was selected as cryoprotectant for freeze-dried simultaneously loaded PLGA nanoparticles. In vitro release study showed that ciprofloxacin, Miconazole, and Fluocinolone Acetonide were released from nanoparticles with theoretical drug loading of 10% w/w. Ciprofloxacin, Miconazole, and Fluocinolone Acetonide showed sustained release for 40 days, while resveratrol showed sustained release for 20 days. These nanoparticles were found to follow the Higuchi diffusion control release model. |
| Keywords: | Nanoparticle, ciprofloxacin, nanotechnology, Miconazole, Fluocinolone, TEM, Particle size |
| Cite Article: | "FORMULATION AND DEVELOPMENT OF CIPROFLOXACIN,MICONAZOLE,AND FLUOCINOLONE ACETONIDE LOADED NANOPARTICLE AND ITS EVALUATION", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 10, page no.c369-c385, October-2023, Available :http://www.ijnrd.org/papers/IJNRD2310242.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2310242 Registration ID: 207249 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): Page No: c369-c385 Country: SOUTH WEST, DELHI, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2310242 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2310242 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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