Paper Title
FORMULATION AND DEVELOPMENT OF CIPROFLOXACIN,MICONAZOLE,AND FLUOCINOLONE ACETONIDE LOADED NANOPARTICLE AND ITS EVALUATION
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Registration ID: IJNRD_207249
Published ID: IJNRD2310242
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Keywords
Nanoparticle, ciprofloxacin, nanotechnology, Miconazole, Fluocinolone, TEM, Particle size
Abstract
In the present study, we have developed and characterized Ciprofloxacin, Miconazole, and Fluocinolone Acetonide simultaneously loaded PLGA nanoparticles to enhance the bioavailability of both the agents, to achieve the therapeutic advantage of the combination and to obtain sustained release of the drug. These nanoparticles have been characterized for their size, morphology, drug loading, and entrapment efficiency and optimized at different theoretical drug loadings and also evaluated in vitro to see their release from the formulation. Nanoparticles were prepared by emulsion-diffusion-evaporation method using PLGA (75/25) at three different drug loadings 5%, 10%, and 15%. The % entrapment efficiency was found to increase with the increase in drug loading from (5% to 15%). The % yield was found to increase from 58% to 80%. The particle size of nanoparticles was found to be 222-283 nm with a polydispersity index below 0.312 and a zeta potential of around -6.0 mV was observed. D- trehalose (10% w/v) was selected as cryoprotectant for freeze-dried simultaneously loaded PLGA nanoparticles. In vitro release study showed that ciprofloxacin, Miconazole, and Fluocinolone Acetonide were released from nanoparticles with theoretical drug loading of 10% w/w. Ciprofloxacin, Miconazole, and Fluocinolone Acetonide showed sustained release for 40 days, while resveratrol showed sustained release for 20 days. These nanoparticles were found to follow the Higuchi diffusion control release model.
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How To Cite (APA)
ANUPAM ANAND & DR.SURESH CHAUDHARY (October-2023). FORMULATION AND DEVELOPMENT OF CIPROFLOXACIN,MICONAZOLE,AND FLUOCINOLONE ACETONIDE LOADED NANOPARTICLE AND ITS EVALUATION. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), c369-c385. https://ijnrd.org/papers/IJNRD2310242.pdf
Issue
Volume 8 Issue 10, October-2023
Pages : c369-c385
Other Publication Details
Paper Reg. ID: IJNRD_207249
Published Paper Id: IJNRD2310242
Research Area: Pharmacy
Author Type: Indian Author
Country: SOUTH WEST, DELHI, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2310242.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310242
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