Paper Title
Exosomes - The Innovative biomarkers in diagnosis and management of Alzheimer's disease
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Registration ID: IJNRD_206665
Published ID: IJNRD2310159
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Keywords
Alzhiemer’s disease, Exosomes, Neurodegenerative disease, cargo, miRNAs, treatment, diagnosis
Abstract
Most eukaryotic cells produce exosomes (EXOs), which are tiny extravascular vesicles (30–150 nm in diameter) in the endosomal compartment. They are present in all eukaryotic fluids and are surrounded by phospholipid bilayers, which facilitate a number of crucial cellular processes. Early-stage identification of Alzheimer's disease (AD) is difficult since there are few reliable biomarkers and limited patient access to diagnostic procedures like imaging and cerebrospinal fluid (CSF) studies. According to recent studies, we can say that exosomes could be innovative diagnostic agents for AD because they contain specific chemicals that may be employed as prospective biomarker candidates for early disease detection and prediction before the development of symptoms. Particularly exosomal proteins and microRNAs (miRNAs), which make up the molecular components of exosomes, show considerable promise as new biomarkers for clinical diagnosis and treatment. Due to their presence in the majority of biological fluids, such as blood, urine, saliva, synovial fluid, amniotic fluid, vaginal fluid, breast milk, semen, etc., their extremely high disease-specific bio-molecular signature or profile, the ability of exosomes to carry and exchange various cargos between cells, and their capacity to cross the blood-brain barrier, there has been an increased interest in using exosomes for the diagnosis of neurodegenerative disorders in recent years. In this review, we will discuss the role of exosomes in the treatment and diagnosis of Alzheimer's disease.
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How To Cite (APA)
G. Supriya Reddy, Adusumilli Mutya Aparna, Komal Singh Shekhawat, Mirdoddi Balaji, & T. Rama Rao (October-2023). Exosomes - The Innovative biomarkers in diagnosis and management of Alzheimer's disease. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), b534-b551. https://ijnrd.org/papers/IJNRD2310159.pdf
Issue
Volume 8 Issue 10, October-2023
Pages : b534-b551
Other Publication Details
Paper Reg. ID: IJNRD_206665
Published Paper Id: IJNRD2310159
Research Area: Life SciencesÂ
Author Type: Indian Author
Country: Hyderabad, Telangana, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2310159.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310159
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