An observational study to determine clinical profile,immunological profile of MCTD patients and adverse events developed during the duration of treatment.

Registration ID: IJNRD_206825

Published ID: IJNRD2310141

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Nandeesh H U , Teena chandran , Amrutha M K

:MCTD,Pneumonia,avascular necrosis

Abstract : Background: Mixed connective tissue disease (MCTD) is a rare autoimmune disease, characterized by the production of specific autoantibody anti-RNP, which presents with varied overlapping symptoms of different connective tissue disorders. The aim of this study is to identify the frequency and patterns of MCTD. Objective :To demonstrate the clinical profile,immunological profile of MCTD patients and adverse events developed during the duration of treatment Design :Prospective observational study Setting : A large, academic, tertiary medical center Methodology:All MCTD cases admitted in Sapthagiri Institute of Medical Sciences and Research Centre was included.Data was collected through a prepared performa.Patients were followed up till death or discharge. Results:All 10 cases of MCTD, U1RNP is positive. 8 of the 10 cases were treated aggressively with immunosuppressants. Most common secondary infection was Pneumonia. One patient developed Abdominal TB One patient developed avascular necrosis of femur secondary to high dose steroids. Interpretation and conclusion:It can be noted that even though the relapse rate was lower among patient treated aggressively the chance of developing secondary infection was very high Hence it is important to monitor the cases which are treated with immunosuppressants, for early diagnosis and treatment of any adverse events.

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Nandeesh H U, Teena chandran, & Amrutha M K (October-2023). An observational study to determine clinical profile,immunological profile of MCTD patients and adverse events developed during the duration of treatment.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), b380-b385. https://ijnrd.org/papers/IJNRD2310141.pdf

Volume 8 Issue 10, October-2023

Pages : b380-b385

Paper Reg. ID: IJNRD_206825

Published Paper Id: IJNRD2310141

Downloads: 000121985

Research Area: Medical Science

Country: Chikkabanavara, Karnataka, India

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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