SOLUBILIZING PROPERTIES OF VOLATILE SOLIDS SHALL REPLACE HAZARDOUS ORGANIC SOLVENTS IN THIN LAYER CHROMATOGRAPHY STUDIES

Registration ID: IJNRD_206669

Published ID: IJNRD2310128

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Chanakshi Joshi, Mrunmayee Jog, Dr. Rajesh Kumar Maheshwari

Thin Layer Chromatography, Organic solvents, Mixed solvency concept, Solubilizers

The pharmaceutical assays and other tests are largely validated by using organic solvents viz butanol, methanol, chloroform, acetone, carbon tetrachloride, chloromethane, benzene, cyclohexane, ether, etc. These above-listed organic solvents also have their applications extended to thin-layer chromatography and other techniques of analysis. However, most of these organic solvents have proved to affect the research personnel in more than one way. They lead to numerous adversities that include headaches, drowsiness, nausea, eye irritation on single exposure and long-term exposure may lead to chronic renal failure, liver damage, neurosis, etc. Also, they are costly and their unsafe disposal might lead to environmental pollution. Hence, they aren't considered safe for frequent usage. On the basis of various experiments on solubilization, it is believed that all substances whether liquids, gasses or solids possess solubilizing powers. With this approach, we have augmented the solubilizing power of the ethanol (comparatively less harmful organic solvent) by preparing the blends of ethanol with co-solvents like Thymol, Menthol and Camphor (organic solids that possess solubilizing power and are less harmful). Later, these blends were used as a mobile phase to perform Thin Layer Chromatography so as to obviate the use of previously used harmful organic solvents. The selected drugs were Nalidixic acid, Nicotinic acid, Metronidazole, Paracetamol and Guaifenesin to carry out the investigation. The spotting of these drugs was done on the TLC plates. Later, these spots were run by using different blends as mobile phases. The mixed solvency concept is cost-effective and also prevents working with harmful organic solvents. Thus, the introduction of the novel method of solubilization can revolutionize the pharmaceutical industry.

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Chanakshi Joshi, Mrunmayee Jog, & Dr. Rajesh Kumar Maheshwari (October-2023). SOLUBILIZING PROPERTIES OF VOLATILE SOLIDS SHALL REPLACE HAZARDOUS ORGANIC SOLVENTS IN THIN LAYER CHROMATOGRAPHY STUDIES. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), b241-b247. https://ijnrd.org/papers/IJNRD2310128.pdf

Volume 8 Issue 10, October-2023

Pages : b241-b247

Paper Reg. ID: IJNRD_206669

Published Paper Id: IJNRD2310128

Downloads: 000121999

Research Area: Pharmacy

Author Type: Indian Author

Country: Indore, Madhya Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310128.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310128

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