An observational study to determine causation, clinical profile and prognosis of pancytopenia in a tertiary care center

Registration ID: IJNRD_206526

Published ID: IJNRD2310079

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Akhil karun , Madhusudhan C , Teenachandran

Aplastic anemia, Bone marrow biopsy, Megaloblastic anemia, Pancytopenia

Objective :To see the clinical profile, etiological factors and laboratory parameters in patients with pancytopenia. Design :Prospective observational study Setting :A large, academic, tertiary medical center Methodology: Clinical and laboratory data of all patients with a primary diagnosis of pancytopenia was taken . The various etiological factors, clinical presentations and lab investigations were taken into account and compared and prognosis was assessed for each patient Results: A male preponderance was observed, and the majority of patients were aged below 60 years. The most common clinical features were pallor and splenomegaly. 67 percent of patients had hemoglobin less than 7 g%; whereas around 50% of the sample had WBC < 2000 and platelets less than 50000, 52 % had vitamin B12 deficiency, 32% had folic acid deficiency and 19% had a deficiency of both. The most common cause of pancytopenia was Vit B12 deficiency ( 52%) , followed by leukemias and plasma cell dyscrasias ( 19%) and aplastic anemia ( 13%) Interpretation and conclusion:  Several easily recognisable and treatable conditions can manifest as pancytopenia. Prompt management of such conditions, notably sepsis and megaloblastic anaemia, can result in the resolution of the cytopenias and negate the need for a BME. Pancytopenia investigations, when guided by appropriate clinic-laboratory findings, can promptly identify the underlying aetiology, while also identifying cases where an expedited BME is required. Key words: Aplastic anemia, Bone marrow biopsy, Megaloblastic anemia, Pancytopenia Corresponding authors :Dr Akhil Karun*,Dr Madhusudhan C**,Dr Teena chandran*** *Post graduate, SIMS&RC, Bangalore **Associate Professor ,SIMS&RC, Bangalore ***Senior Resident, SIMS&RC, Bangalore

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Akhil karun, Madhusudhan C, & Teenachandran (October-2023). An observational study to determine causation, clinical profile and prognosis of pancytopenia in a tertiary care center. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(10), a701-a706. https://ijnrd.org/papers/IJNRD2310079.pdf

Volume 8 Issue 10, October-2023

Pages : a701-a706

Paper Reg. ID: IJNRD_206526

Published Paper Id: IJNRD2310079

Downloads: 000121990

Research Area: Health Science 

Country: Bangalore, karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310079.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310079

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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