Design and Synthesis of some Novel Heterocyclic Compounds of Triazoles of Biological Interest.

Design and Synthesis of some Novel Heterocyclic Compounds of Triazoles of Biological Interest.

Registration ID: IJNRD_206306

Published ID: IJNRD2310037

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Pankaj Tadge , Dr. Parul Mehta

On the basis of various literature survey, triazole derivatives show various activity such as antibacterial, anti-inflammatory, antifungal, anticonvulsant, antitubercular, antioxidant, COX-2 inhibition, antimicrobial and anticancer activity. The possible improvements in the activity can be further achieved by slight modifications in the substituents on the basic triazole nucleus. As this moiety have remarkable biological activities which stimulated the research work in the field of heterocyclic chemistry. Hence it is intended for the synthesis, characterization and evaluation of biological activity of various types of derivatives belonging to the above classes of heterocyclic compounds. Prompted by the broad spectrum activities of triazole, series of 2-[(4-substituted)-5-mercapto-4H-1,2,4-triazol-3-yl]phenol (3a- 3f) and 3-[3-(2-hydroxyphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl]-2-substituted thiazolidin-4-one (4a-4f) were designed and synthesized by reacting methyl salicylate with hydrazine hydrate. All these synthesize compounds were test for their antibacterial and anti-inflammatory activity.

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"Design and Synthesis of some Novel Heterocyclic Compounds of Triazoles of Biological Interest.", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 10, page no.a310-a322, October-2023, Available :https://ijnrd.org/papers/IJNRD2310037.pdf

Volume 8 Issue 10, October-2023

Pages : a310-a322

Paper Reg. ID: IJNRD_206306

Published Paper Id: IJNRD2310037

Downloads: 000121175

Research Area: Pharmacy

Country: District Betul, Madhya Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2310037.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2310037

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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