Persistent pneumonia in an infant with achalasia cardia due to non-tuberculous mycobacterium

Registration ID: IJNRD_205936

Published ID: IJNRD2309388

DOI: http://doi.one/10.1729/Journal.36352

Dr.Atiullah Mahbullah Khan , Dr. Pradeep Kumar Ranabijuli , Dr. Deepak Salgare , Dr. Nazparveen , Dr. Ayesha Khan

Non-tuberculous mycobacteria, Achalasia cardia, Pneumonia, Barium swallow, gastroesophageal reflux disease, Aerosolization, Cystic fibrosis)

Background Non-tuberculous mycobacteria (NTM) are a large family of acid-fast bacteria, widespread in the environment. In children, NTM cause lymphadenitis, skin and soft tissue infections, and occasionally lung disease and disseminated infections. These manifestations can be indistinguishable from tuberculosis (TB) on the basis of clinical and radiological findings and tuberculin skin testing. Treatment of NTM infections is different from the treatment of TB and depends on the strain and anatomical site of infection and often involves antibiotic combinations, surgery, or both. Case characteristics A 2-month-old infant girl had fever and progressive breathing difficulty at 1.5 months of age. She was formula-fed and had failure to thrive (birth weight 3kg, admission weight 3.3kg). X-rays revealed persistent bilateral consolidation. High resolution computed tomography (HRCT) of the chest revealed air space opacification in the right upper and left lower lobes. A bronchoscopy done revealed gastro-oesophageal reflux disease and BAL culture revealed multidrug resistant (MDR) Klebsiella pneumoniae which was treated with Inj. meropenem and Inj. cotrimoxazole as per sensitivity for 14 days. Though the child was weaned to oxygen support, she had re-appearance of fever and distress. TB culture (MGIT culture) revealed NTM; sensitive drugs rifampin, ethambutol and ofloxacin were given for 1 year, with close follow up and she is well on follow-up (current weight 8.3kg and length 71cm) Message The isolation of an NTM organism does not necessarily equate with active infection; clinical, radiologic, and microbiologic parameters are all needed to establish the diagnosis of infection. Eradication of disease with drug therapy requires prolonged combination therapy. Surgical resection is often indicated in localized disease, in the presence of drug resistant organisms, or in some cases, of failure of medical therapy.

Published Paper   E-Certificate

Dr.Atiullah Mahbullah Khan, Dr. Pradeep Kumar Ranabijuli , Dr. Deepak Salgare , Dr. Nazparveen , & Dr. Ayesha Khan (September-2023). Persistent pneumonia in an infant with achalasia cardia due to non-tuberculous mycobacterium. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(9), d736-d739. http://doi.one/10.1729/Journal.36352

Volume 8 Issue 9, September-2023

Pages : d736-d739

Paper Reg. ID: IJNRD_205936

Published Paper Id: IJNRD2309388

Downloads: 000121990

Research Area: Medical Science

Country: Mumbai, MAHARASHTRA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2309388.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2309388

Crossref DOI: http://doi.one/10.1729/Journal.36352

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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