Warfarin And Its Interactions With Statins And Amiodarone

Registration ID: IJNRD_205620

Published ID: IJNRD2309244

DOI: Click Here to Get

Arshiya Jahan , Mohammed Junaid Javed , Nishath , Dr.A.V Kishore babu , Dr.A.Srinivasa Rao

Warfarin, Amiodarone, Statins, INR, CYP2C9

This is a comparative review which highlights the interactions of warfarin with statins and amiodarone. Warfarin is used in patients with thromboembolism and is commonly prescribed oral anticoagulant which is a vitamin-k antagonist. Drugs like statins and amiodarone are prescribed for atrial fibrillation and myocardial ischemia simultaneously with warfarin leading to potential drug interaction. Even though these drugs are frequently prescribed with warfarin clinical guidelines on these drug combinations are divergent. Warfarin is highly effective and safe but both efficacy and safety depend upon blood international normalized ratio. Monitoring INR and dose adjustment can be beneficial for effective warfarin therapy. Warfarin, statins and amiodarone are metabolized by Cyt-p450 enzymes leading to possible interactions. Warfarin, when co-administered with statins, inhibits the metabolic pathway of statins causing increased pharmacological action of statins leading to increased risk of drug toxicity and rhabdomyolysis whereas when warfarin is co-administered with Amiodarone, amiodarone inhibits the metabolic pathway of warfarin causing increased anticoagulant effect. The metabolic pathway of warfarin not only interacts with cardiovascular agents but also many dietary supplements making it necessary to monitor the therapy. The main goal of anticoagulation therapy with warfarin should be to administer least effective dose possible that obtains the required International normalized ratio. The initiation of warfarin can be more challenging due to its narrow therapeutic index and pharmacodynamic response is highly unpredictable due to varied individual susceptibility.

Published Paper   E-Certificate

Arshiya Jahan, Mohammed Junaid Javed, Nishath, Dr.A.V Kishore babu, & Dr.A.Srinivasa Rao (September-2023). Warfarin And Its Interactions With Statins And Amiodarone. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(9), c388-c391. https://ijnrd.org/papers/IJNRD2309244.pdf

Volume 8 Issue 9, September-2023

Pages : c388-c391

Paper Reg. ID: IJNRD_205620

Published Paper Id: IJNRD2309244

Downloads: 000121977

Research Area: Pharmacy

Country: Hyderabad, Telangana, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2309244.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2309244

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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