IN-VITRO STUDIES ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY EFFECTS OF METHANOLIC EXTRACT OF LEAVES OF AEGLE MARMELOS

IN-VITRO STUDIES ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY EFFECTS OF METHANOLIC EXTRACT OF LEAVES OF AEGLE MARMELOS

Registration ID: IJNRD_204768

Published ID: IJNRD2308447

DOI: Click Here to Get

T. KUMARESUBITHA , J.Kavina

In-vitro studies, α-Amylase, α-Glucosidase, Methanolic extraction, Aegle marmelos.

Diabetes is one of the world's greatest health problems, affecting about 171 million people and most of these will be dominated by those suffering from type 2 diabetes. This increasing trend in type 2 diabetes mellitus has become a serious medical concern worldwide, which accounts for 9% of deaths that prompts every effort in exploring for new therapeutic agents to stem its progress. Although the drug treatment for type 2 diabetes mellitus has been improved to some extent during the last decade, drug resistance is still a big concern that needs to be dealt with effective approaches. One of the strategies to monitor blood glucose for type II diabetes mellitus is to either inhibit or reduce the production of glucose from the small intestine. In the present investigation methanol extract of leaves of Aegle marmelos was screened for phytochemical analysis and α-amylase and α-glucosidase inhibitory effects were studied in vitro. α-amylase and α-glucosidase inhibitors interfere with the digestion of carbohydrates, achieving better glycemic control. Thus, natural products of great structural diversity are still a good source for searching for such inhibitors, thereby motivating to explore biologically active compounds from the highly diverse plants. In our study methanol extract of leaves of Aegle marmelos inhibit the α-amylase and α-glucosidase might be due to the presence of several phytochemicals such as flavonoid, steroid, alkaloid, saponin, triterpenoid, quinone, tannins, coumarin, and phenol in it. Plants have been a good source of medicine for the treatment of various type of disease, still many plants and active compounds obtained from plants have not been well characterized. More investigations must be carried out to evaluate the exact mechanism of action of medicinal plants with antidiabetic activity.

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"IN-VITRO STUDIES ON α-AMYLASE AND α-GLUCOSIDASE INHIBITORY EFFECTS OF METHANOLIC EXTRACT OF LEAVES OF AEGLE MARMELOS", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 8, page no.e453-e482, August-2023, Available :https://ijnrd.org/papers/IJNRD2308447.pdf

Volume 8 Issue 8, August-2023

Pages : e453-e482

Paper Reg. ID: IJNRD_204768

Published Paper Id: IJNRD2308447

Downloads: 000121190

Research Area: Science & Technology

Country: Chennai, Chennai, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2308447.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2308447

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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