Paper Title
Evaluation of CNS Depressant Activity of Different Plant parts of Aegle marmelos Linn
Article Identifiers
Authors
jitendra jaiswal , jitendra jaiswal , DR. Vivekanand katare
Keywords
Keywords: Aegle marmelosL., behavioral study, CNS depressant activity, histamine, serotonin
Abstract
The present study was carried out with the water-soluble portion of the ethanol extracts of flowers, barks, seeds and leaves of Linn. Aegle marmelos The ethanol extracts of the plant parts were obtained by soxhlet extraction. After performing the gross behavioral study, the CNS depressant activity was evaluated by observing the prolongation of sleeping time induced by pentobarbital sodium in mice. Attempts have been made to explore the possible mechanism behind this activity by determining their effect on brain monoamine neurotransmitters like dopamine and serotonin. The gross behavioral study showed that ethanol extracts of the leaves, flowers and seeds possess significant CNS depressant activity. The leaves, flowers, seeds and barks (600 mg/kg) showed significant and dose-dependent prolongation of onset and duration of sleep and so found to cause decrease dopamine and increase serotonin level. From which it can be concluded that the CNS depressant activity of the ethanol extracts of seeds, leaves and flowers may be due to the decrease in dopamine and increase in serotonin level.
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How To Cite (APA)
jitendra jaiswal, jitendra jaiswal, & DR. Vivekanand katare (August-2023). Evaluation of CNS Depressant Activity of Different Plant parts of Aegle marmelos Linn. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(8), c391-c399. https://ijnrd.org/papers/IJNRD2308254.pdf
Issue
Volume 8 Issue 8, August-2023
Pages : c391-c399
Other Publication Details
Paper Reg. ID: IJNRD_203170
Published Paper Id: IJNRD2308254
Downloads: 000121979
Research Area: Pharmacy
Country: mahuagaon district singrauli, Madhya Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2308254.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2308254
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