Evaluation of CNS Depressant Activity of Different Plant parts of Aegle marmelos Linn

Evaluation of CNS Depressant Activity of Different Plant parts of Aegle marmelos Linn

Registration ID: IJNRD_203170

Published ID: IJNRD2308254

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jitendra jaiswal , jitendra jaiswal , DR. Vivekanand katare

Keywords: Aegle marmelosL., behavioral study, CNS depressant activity, histamine, serotonin

The present study was carried out with the water-soluble portion of the ethanol extracts of flowers, barks, seeds and leaves of Linn. Aegle marmelos The ethanol extracts of the plant parts were obtained by soxhlet extraction. After performing the gross behavioral study, the CNS depressant activity was evaluated by observing the prolongation of sleeping time induced by pentobarbital sodium in mice. Attempts have been made to explore the possible mechanism behind this activity by determining their effect on brain monoamine neurotransmitters like dopamine and serotonin. The gross behavioral study showed that ethanol extracts of the leaves, flowers and seeds possess significant CNS depressant activity. The leaves, flowers, seeds and barks (600 mg/kg) showed significant and dose-dependent prolongation of onset and duration of sleep and so found to cause decrease dopamine and increase serotonin level. From which it can be concluded that the CNS depressant activity of the ethanol extracts of seeds, leaves and flowers may be due to the decrease in dopamine and increase in serotonin level.

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"Evaluation of CNS Depressant Activity of Different Plant parts of Aegle marmelos Linn", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 8, page no.c391-c399, August-2023, Available :https://ijnrd.org/papers/IJNRD2308254.pdf

Volume 8 Issue 8, August-2023

Pages : c391-c399

Paper Reg. ID: IJNRD_203170

Published Paper Id: IJNRD2308254

Downloads: 000121144

Research Area: Pharmacy

Country: mahuagaon district singrauli, Madhya Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2308254.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2308254

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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