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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS |
| Authors Name: | Mr. Mrinal Shakyawar , Ms. Sana Sahil , Dr. C.K. Tyagi , Ms.Deepshikha Gunwan , Ms.Nida Faheem |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_203182
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| Published Paper Id: | IJNRD2308064 |
| Published In: | Volume 8 Issue 8, August-2023 |
| DOI: | |
| Abstract: | The objective of the present work is to design of sustained release matrix tablets of Dolasetron influence of polymers, on the release rate and in vitro evaluation. Dolasetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. The polymers are HPMCK4M, HPMC K15 M, Lactose, Talcum, Magnesium Stearate, Colloidal silicon dioxide were utilized in the formulation of matrix tablets containing Dolasetron evaluated for its in-vitro drug release. Granules were prepared and evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. Formulation was optimized on the basis of acceptable tablet properties (hardness, friability, drug content and weight variations), in vitro drug release and stability studies. All the formulations showed compliance with Pharmacopeial standards. The in vitro release study of matrix tablets were carried out in pH 1.2 HCl for 2 hours and pH 7.4 phosphate buffer for the remaining 10 hours as dissolution medium. The results indicated that a decrease in release kinetics of the drug was observed by increasing the polymer concentration. The stability studies were carried out according to ICH guideline which indicates that the selected formulations were stable. |
| Keywords: | Sustained release tablets, Dolasetron, Lactose, Talcum, Magnesium Stearate, Colloidal silicon dioxide |
| Cite Article: | "DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 8, page no.a534-a545, August-2023, Available :http://www.ijnrd.org/papers/IJNRD2308064.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2308064 Registration ID: 203182 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: a534-a545 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2308064 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2308064 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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