DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS

Registration ID: IJNRD_203182

Published ID: IJNRD2308064

DOI: Click Here to Get

Mr. Mrinal Shakyawar , Ms. Sana Sahil , Dr. C.K. Tyagi , Ms.Deepshikha Gunwan , Ms.Nida Faheem

Sustained release tablets, Dolasetron, Lactose, Talcum, Magnesium Stearate, Colloidal silicon dioxide

The objective of the present work is to design of sustained release matrix tablets of Dolasetron influence of polymers, on the release rate and in vitro evaluation. Dolasetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. The polymers are HPMCK4M, HPMC K15 M, Lactose, Talcum, Magnesium Stearate, Colloidal silicon dioxide were utilized in the formulation of matrix tablets containing Dolasetron evaluated for its in-vitro drug release. Granules were prepared and evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. Formulation was optimized on the basis of acceptable tablet properties (hardness, friability, drug content and weight variations), in vitro drug release and stability studies. All the formulations showed compliance with Pharmacopeial standards. The in vitro release study of matrix tablets were carried out in pH 1.2 HCl for 2 hours and pH 7.4 phosphate buffer for the remaining 10 hours as dissolution medium. The results indicated that a decrease in release kinetics of the drug was observed by increasing the polymer concentration. The stability studies were carried out according to ICH guideline which indicates that the selected formulations were stable.

Published Paper   E-Certificate

Mr. Mrinal Shakyawar, Ms. Sana Sahil, Dr. C.K. Tyagi, Ms.Deepshikha Gunwan, & Ms.Nida Faheem (August-2023). DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(8), a534-a545. https://ijnrd.org/papers/IJNRD2308064.pdf

Volume 8 Issue 8, August-2023

Pages : a534-a545

Paper Reg. ID: IJNRD_203182

Published Paper Id: IJNRD2308064

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Research Area: Engineering

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Published Paper PDF: https://ijnrd.org/papers/IJNRD2308064.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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