Molecular Background of Low Back Pain

Molecular Background of Low Back Pain

Registration ID: IJNRD_203046

Published ID: IJNRD2308026

DOI: Click Here to Get

Hrisab deb , Debajit sarma , Sabir hussain

Intervertebral disc degeneration is a major cause of low back pain and disability around the world. The nucleus pulposus (gelatinous core), annulus fibrosus (fibrous outer ring), and cartilage endplates make up the disc. Disc degeneration causes structural, morphological, and functional alterations. Fissures in the annulus fibrosus might contribute to disc herniation. Intervertebral disc prolapse, which is caused by degeneration, is a prevalent cause of low back discomfort. Alterations in the vertebral endplates, evident on MRI as medic alterations, are also linked to disc degeneration and low back pain. Uncontrolled cell growth, cell death, and cell senescence occur during disc degeneration. The provision of nutrients to disc cells is crucial, and disruptions in blood supply can cause degeneration. Mechanical stress and damage can both start the degenerative process-rays are used for initial assessment, and MRI is used for enhanced visualisation of soft tissue. Kinetic MRI in weight-bearing situations can detect problems that static scans cannot. RI Pfirrman grading evaluates disc degeneration. Proteoglycans, which contain covalently linked glycosaminoglycans (GAGs), are essential for disc hydration and function. GAGs are sulphated glycans that are linear and heterogeneous. Low back pain is a widespread and incapacitating complaint that, despite advanced imaging, frequently has an unexplained explanation. MR imaging reveals morphological changes associated with ageing in the absence of symptoms. Molecular alterations, such as proteolytic enzymes and inflammatory cytokines, are important in disc degeneration and modify the MR signal. Understanding these alterations can help with the specific treatment of low back pain.

Published Paper   E-Certificate

"Molecular Background of Low Back Pain ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 8, page no.a218-a226, August-2023, Available :https://ijnrd.org/papers/IJNRD2308026.pdf

Volume 8 Issue 8, August-2023

Pages : a218-a226

Paper Reg. ID: IJNRD_203046

Published Paper Id: IJNRD2308026

Downloads: 000121125

Research Area: Health Science 

Country: Jorhat, Assam, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2308026.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2308026

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

IJNRD is Scholarly open access journals, Peer-reviewed, and Refereed Journals, High Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool), Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) with Open-Access Publications.

INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

Indexing In Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar | AI-Powered Research Tool, Microsoft Academic, Academia.edu, arXiv.org, Research Gate, CiteSeerX, ResearcherID Thomson Reuters, Mendeley : reference manager, DocStoc, ISSUU, Scribd, and many more

How to submit the paper?

Important Dates for Current issue

Paper Submission Open For: August 2025

Current Issue: Volume 10 | Issue 8

Last Date for Paper Submission: Till 31-Aug-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: International Peer-reviewed, Refereed, and Open Access Journal.

Subject Category: Research Area