Molecular Background of Low Back Pain

Registration ID: IJNRD_203046

Published ID: IJNRD2308026

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Hrisab deb, Debajit sarma, Sabir hussain

Intervertebral disc degeneration is a major cause of low back pain and disability around the world. The nucleus pulposus (gelatinous core), annulus fibrosus (fibrous outer ring), and cartilage endplates make up the disc. Disc degeneration causes structural, morphological, and functional alterations. Fissures in the annulus fibrosus might contribute to disc herniation. Intervertebral disc prolapse, which is caused by degeneration, is a prevalent cause of low back discomfort. Alterations in the vertebral endplates, evident on MRI as medic alterations, are also linked to disc degeneration and low back pain. Uncontrolled cell growth, cell death, and cell senescence occur during disc degeneration. The provision of nutrients to disc cells is crucial, and disruptions in blood supply can cause degeneration. Mechanical stress and damage can both start the degenerative process-rays are used for initial assessment, and MRI is used for enhanced visualisation of soft tissue. Kinetic MRI in weight-bearing situations can detect problems that static scans cannot. RI Pfirrman grading evaluates disc degeneration. Proteoglycans, which contain covalently linked glycosaminoglycans (GAGs), are essential for disc hydration and function. GAGs are sulphated glycans that are linear and heterogeneous. Low back pain is a widespread and incapacitating complaint that, despite advanced imaging, frequently has an unexplained explanation. MR imaging reveals morphological changes associated with ageing in the absence of symptoms. Molecular alterations, such as proteolytic enzymes and inflammatory cytokines, are important in disc degeneration and modify the MR signal. Understanding these alterations can help with the specific treatment of low back pain.

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Hrisab deb, Debajit sarma, & Sabir hussain (August-2023). Molecular Background of Low Back Pain . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(8), a218-a226. https://ijnrd.org/papers/IJNRD2308026.pdf

Volume 8 Issue 8, August-2023

Pages : a218-a226

Paper Reg. ID: IJNRD_203046

Published Paper Id: IJNRD2308026

Research Area: Health Science 

Author Type: Indian Author

Country: Jorhat, Assam, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2308026.pdf

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