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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Molecular Background of Low Back Pain |
| Authors Name: | Hrisab deb , Debajit sarma , Sabir hussain |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_203046
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| Published Paper Id: | IJNRD2308026 |
| Published In: | Volume 8 Issue 8, August-2023 |
| DOI: | |
| Abstract: | Intervertebral disc degeneration is a major cause of low back pain and disability around the world. The nucleus pulposus (gelatinous core), annulus fibrosus (fibrous outer ring), and cartilage endplates make up the disc. Disc degeneration causes structural, morphological, and functional alterations. Fissures in the annulus fibrosus might contribute to disc herniation. Intervertebral disc prolapse, which is caused by degeneration, is a prevalent cause of low back discomfort. Alterations in the vertebral endplates, evident on MRI as medic alterations, are also linked to disc degeneration and low back pain. Uncontrolled cell growth, cell death, and cell senescence occur during disc degeneration. The provision of nutrients to disc cells is crucial, and disruptions in blood supply can cause degeneration. Mechanical stress and damage can both start the degenerative process-rays are used for initial assessment, and MRI is used for enhanced visualisation of soft tissue. Kinetic MRI in weight-bearing situations can detect problems that static scans cannot. RI Pfirrman grading evaluates disc degeneration. Proteoglycans, which contain covalently linked glycosaminoglycans (GAGs), are essential for disc hydration and function. GAGs are sulphated glycans that are linear and heterogeneous. Low back pain is a widespread and incapacitating complaint that, despite advanced imaging, frequently has an unexplained explanation. MR imaging reveals morphological changes associated with ageing in the absence of symptoms. Molecular alterations, such as proteolytic enzymes and inflammatory cytokines, are important in disc degeneration and modify the MR signal. Understanding these alterations can help with the specific treatment of low back pain. |
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| Cite Article: | "Molecular Background of Low Back Pain ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 8, page no.a218-a226, August-2023, Available :http://www.ijnrd.org/papers/IJNRD2308026.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2308026 Registration ID: 203046 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: a218-a226 Country: Jorhat, Assam, India Research Area: Health Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2308026 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2308026 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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