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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Commiphora mukul Nanoparticulate Drug Delivery System for Rheumatoid Arthritis: Design, Development, Characterization, and Preclinical Investigation |
| Authors Name: | Patil Chetana Dnyandeo , Dr.V. R. Salunkhe |
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IJNRD_202900
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| Published Paper Id: | IJNRD2307481 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | The study's objective is to evaluate the improved therapeutic efficacy and decreased toxicity of Commiphora mukul nanoparticulate drug administration for rheumatoid arthritis. The active chemical components of Commiphora mukul were initially separated via extraction and column chromatography. Additionally, Commiphora mukul extract nanoparticles were prepared and assessed using various metrics and methods following a positive assessment of the nanoparticles, Tablet formulations were developed and tested for anti-rheumatoid arthritis activity, stability, in vitro drug release and different evaluation parameters. Particle size analysis, SEM, and TEM results indicated that the produced nanoparticles had the appropriate size and morphology. The acute toxicity study was performed, and it suggested that the prepared nanoparticles had less toxicity. According to the stability study, they had a 3-month shelf life and a 90% drug entrapment rate.After 60 minutes, all 12 batches of Tablet formulations released more than 70% of the medication they contained, while five batches released more than 90%.According to the accelerated stability study, the initial drug release from the best batch was 92.5%, and six months later, it was 91.1%.While other parameters like thickness, weight variation, hardness, and friability continue to fall within acceptable ranges with minimal modifications. The result of preclinical research revealed that prepared nanoparticulate formulations responded better than standard and control formulations. According to anti-rheumatoid arthritis activity tests, the produced formulation had improved therapeutic efficacy and decreased toxicity. Patients with rheumatoid arthritis can benefit more from this formulation. |
| Keywords: | Rheumatoid arthritis, Commiphora mukul, Nanoparticles, Drug delivery, Preclinical study, Drug development |
| Cite Article: | "Commiphora mukul Nanoparticulate Drug Delivery System for Rheumatoid Arthritis: Design, Development, Characterization, and Preclinical Investigation", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 7, page no.e664-e695, July-2023, Available :http://www.ijnrd.org/papers/IJNRD2307481.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2307481 Registration ID: 202900 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: e664-e695 Country: Malkapur, MAHARASHTRA, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2307481 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2307481 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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