Paper Title
Commiphora mukul Nanoparticulate Drug Delivery System for Rheumatoid Arthritis: Design, Development, Characterization, and Preclinical Investigation
Article Identifiers
Authors
Patil Chetana Dnyandeo , Dr.V. R. Salunkhe
Keywords
Rheumatoid arthritis, Commiphora mukul, Nanoparticles, Drug delivery, Preclinical study, Drug development
Abstract
The study's objective is to evaluate the improved therapeutic efficacy and decreased toxicity of Commiphora mukul nanoparticulate drug administration for rheumatoid arthritis. The active chemical components of Commiphora mukul were initially separated via extraction and column chromatography. Additionally, Commiphora mukul extract nanoparticles were prepared and assessed using various metrics and methods following a positive assessment of the nanoparticles, Tablet formulations were developed and tested for anti-rheumatoid arthritis activity, stability, in vitro drug release and different evaluation parameters. Particle size analysis, SEM, and TEM results indicated that the produced nanoparticles had the appropriate size and morphology. The acute toxicity study was performed, and it suggested that the prepared nanoparticles had less toxicity. According to the stability study, they had a 3-month shelf life and a 90% drug entrapment rate.After 60 minutes, all 12 batches of Tablet formulations released more than 70% of the medication they contained, while five batches released more than 90%.According to the accelerated stability study, the initial drug release from the best batch was 92.5%, and six months later, it was 91.1%.While other parameters like thickness, weight variation, hardness, and friability continue to fall within acceptable ranges with minimal modifications. The result of preclinical research revealed that prepared nanoparticulate formulations responded better than standard and control formulations. According to anti-rheumatoid arthritis activity tests, the produced formulation had improved therapeutic efficacy and decreased toxicity. Patients with rheumatoid arthritis can benefit more from this formulation.
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How To Cite (APA)
Patil Chetana Dnyandeo & Dr.V. R. Salunkhe (July-2023). Commiphora mukul Nanoparticulate Drug Delivery System for Rheumatoid Arthritis: Design, Development, Characterization, and Preclinical Investigation. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(7), e664-e695. https://ijnrd.org/papers/IJNRD2307481.pdf
Issue
Volume 8 Issue 7, July-2023
Pages : e664-e695
Other Publication Details
Paper Reg. ID: IJNRD_202900
Published Paper Id: IJNRD2307481
Downloads: 000121979
Research Area: Pharmacy
Country: Malkapur, MAHARASHTRA, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2307481.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2307481
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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