ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TARTARIC ACID FROM EFFERVESCENT GRANULES BY RP-HPLC

Registration ID: IJNRD_202278

Published ID: IJNRD2307376

DOI: http://doi.one/10.1729/Journal.35364

Dr. Ameya Mulay , Harshali Thakare , Sudhir Shinde , Mahendra Godase , Suhas Wale

HPLC, Tartaric Acid, Effervescent, Analytical Method Development

The analytical method was developed and validated for Tartaric acid Effervescent formulation by using RP- HPLC. The appropriate meth-od optimized for the assay of Tartaric acid and validated as per ICH 2005 guidelines. For the analysis, 210 nm wavelength on UV/visible detector were selected, with the Mobile phase 0.01 M Potassium Dihydrogen Phosphate, pH 2.6. maintained with Orthophosphoric Acid. The chromatographic conditions for the best separation of Tartaric acid, RP-column C18 Shimadzu GIST Shim Pack (4.6 x 250 mm, 5 μm particle size) with a flow rate of 1.0 mL/ min, and injection volume of 20 µL. The oven is set to a temperature of around 30 °C. The method was validated for specificity, linearity, precision, accuracy, and robustness. The developed method was found to be linear and precision was evaluated by replicate analysis in which Relative Standard Deviation (RSD) values for areas were found below 2.0%. The recoveries ob-tained (100.83%–101.54%) ensured the accuracy of the developed method. Accordingly, the proposed developed and validated procedure was proved to be suitable for routine analysis of Tartaric acid.

Published Paper   E-Certificate

Dr. Ameya Mulay, Harshali Thakare, Sudhir Shinde, Mahendra Godase, & Suhas Wale (July-2023). ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TARTARIC ACID FROM EFFERVESCENT GRANULES BY RP-HPLC. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(7), d662-d667. http://doi.one/10.1729/Journal.35364

Volume 8 Issue 7, July-2023

Pages : d662-d667

Paper Reg. ID: IJNRD_202278

Published Paper Id: IJNRD2307376

Downloads: 000121991

Research Area: Pharmacy

Country: Mumbai, Maharashtra, India

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Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2307376

Crossref DOI: http://doi.one/10.1729/Journal.35364

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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