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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Role of Protein Tyrosine Phosphatase in Type-2 Diabetes Mellitus Patients. |
| Authors Name: | Charu bala Asthana |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_201919
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| Published Paper Id: | IJNRD2307371 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | Blood glucose level is regulated through insulin.Insulin resistance is mostly caused by impairment in the insulin receptor (IR) signal transduction pathway which is the most important characteristic of type-2 diabetes mellitus(T2DM).The evidence for the physiological role of PTP1B in the regulation of metabolic pathways came from whole body PTP1B knock out mice.The increased incidence of T2DM has intensified search for new therapeutic treatment options.PTP’s constitute a large family of enzymes which are crucial modulators of cellular phosphorylation events.Recent studies have demonstrated that loss of PTP1B activity resulted in insulin resistance.PTP1B is able to interact with IR & IRS-I to hydrolyse tyrosine phosphorylation induced by insulin action,causing an impairment of glucose uptake.The present study was conducted in CSSH,Meerut in the year 2008.100 controls & 100,T2DM patients of age 40-60 years were included for the study.Decrease in PTP1B can help in the assessment and treatment of T2DM patients. |
| Keywords: | IR-Insulin Receptor,IRS-1-Insulin Receptor Substrate,PTP1B-Protein Tyrosine Phosphatase,T2DM-Type2Diabetes Mellitus,RTK-Receptor Tyrosine Kinase & PI3K-Phosphatidylinositol 3 Kinase. |
| Cite Article: | "Role of Protein Tyrosine Phosphatase in Type-2 Diabetes Mellitus Patients.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 7, page no.d612-d622, July-2023, Available :http://www.ijnrd.org/papers/IJNRD2307371.pdf |
| Downloads: | 000118756 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2307371 Registration ID: 201919 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: d612-d622 Country: Dehradun, Uttarakhand, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2307371 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2307371 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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