Synthesis of some Newer Pyrimidine Derivatives as Antimalarial Agents

Registration ID: IJNRD_201846

Published ID: IJNRD2307285

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Sanjeev Saket , Dr. Parul Mehta , Dr. Govind Nayak , Mr. Mukesh Pawar

Docking, Pyrimidine, Uracil, Thymidine, Cytosine and Antimalarial activity

Five compounds were synthesized using the synthetic scheme that was derived from the works of Panda and Ram. The synthesis of 3, 4-dihydropyrimidine was performed by using substituted benzaldehyde, urea and ethylacetoacetate as depicted in the section below by Biginelli condensation. The hydrazide derivative of the dihydropyrimidine-2-one was synthesized by the treatment of the product of step 1 by hydrazine hydrate in presence of ethanol with catalytic amount of concentrated sulfuric acid. The triazolo derivatives were synthesized by the condensation of the hydrazide derivative, ammonium acetate and an aldehyde in the presence of acetic acid. The product precipitated on neutralization with ammonia solution. Alkylation of the pyrimidine derivatives obtained in the step 3 was accomplished by the treatment with alkyl halide and K2CO3 in presence of DMF. The compounds were obtained in the yield of 68 to 80% and were off white to pale yellow in color. All the compounds were soluble in water and DMSO, slightly soluble in methanol and insoluble in chloroform.

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Sanjeev Saket, Dr. Parul Mehta, Dr. Govind Nayak, & Mr. Mukesh Pawar (July-2023). Synthesis of some Newer Pyrimidine Derivatives as Antimalarial Agents. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(7), c869-c878. https://ijnrd.org/papers/IJNRD2307285.pdf

Volume 8 Issue 7, July-2023

Pages : c869-c878

Paper Reg. ID: IJNRD_201846

Published Paper Id: IJNRD2307285

Downloads: 000121988

Research Area: Pharmacy

Country: Bhopal, Madhya Pradesh, India

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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