REACTIVE OXYGEN SPECIES (ROS): A BRIGHT MOON TOWARDS CANCER THERAPY- A Review

Registration ID: IJNRD_201301

Published ID: IJNRD2307268

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Pooja. P. Dahale , Dr. Pawar Anil Raosaheb

Cancer, Reactive oxygen species (ROS), Free Radicals (FR), Signaling pathways, redox-homeostasis.

Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherapeutics is due to the induction of oxidative stress and ROS-mediated cell injury in cancer. Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rate, gene mutation and relative hypoxia, and excess ROS are quenched by increased antioxidant enzymatic and nonenzymatic pathways in the same cells. Our review will emphasize the molecular mechanisms useful for the development of therapeutic strategies that are based on modulating ROS levels to treat cancer. In the late 1950's free radicals (FR) and antioxidants were almost unheard of in the clinical and biological sciences but chemists had known about them for years in the context of radiation, polymer and combustion technology.

Published Paper   E-Certificate

Pooja. P. Dahale & Dr. Pawar Anil Raosaheb (July-2023). REACTIVE OXYGEN SPECIES (ROS): A BRIGHT MOON TOWARDS CANCER THERAPY- A Review. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(7), c690-c698. https://ijnrd.org/papers/IJNRD2307268.pdf

Volume 8 Issue 7, July-2023

Pages : c690-c698

Paper Reg. ID: IJNRD_201301

Published Paper Id: IJNRD2307268

Downloads: 000121981

Research Area: Pharmacy

Country: pune, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2307268.pdf

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