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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Formulation and Evaluation of Atorvastatin tablets using different superdisintegrating agents and its IVIVC study |
| Authors Name: | Bhawani Tripathee , Kashif Hussain , Roshani Prajapati |
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| Author Reg. ID: |
IJNRD_201469
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| Published Paper Id: | IJNRD2307206 |
| Published In: | Volume 8 Issue 7, July-2023 |
| DOI: | |
| Abstract: | This article aimed to formulate and evaluate an optimized formulation of atorvastatin using super disintegrants and investigate the in vitro-in vivo correlation (IVIVC) of the developed formulation. A systematic approach was employed to study the compatibility between atorvastatin and various super disintegrants through drug-excipient compatibility studies. Different formulations were developed using various concentrations of the selected super disintegrants, along with other excipients such as diluents, binders, and lubricants. The formulations were evaluated for various parameters including hardness, friability, weight variation, disintegration time, and drug release profile. Furthermore, In vitro in vivo correlation (IVIVC) predicts in vivo performance of products from in vitro (dissolution) data which overcomes the disadvantages of in vivo study for bioequivalence. Thus, a dissolution study was carried and their plasma drug concentration was determined using this Numerical convolution technique. In conclusion, the formulation and evaluation of atorvastatin tablets using super disintegrants proved to be effective in improving drug dissolution and enhancing disintegration properties. The IVIVC study established a valuable correlation between the in vitro and in vivo performance, providing a predictive tool for the optimization of atorvastatin formulations. These findings contribute to the development of a more efficient and reliable formulation of atorvastatin, with the potential to improve its therapeutic efficacy and patient compliance. |
| Keywords: | Atorvastatin tablets, superdisinegrating agents,compatibility study,IVIVC,methods,Result and discussion,Conclusion |
| Cite Article: | "Formulation and Evaluation of Atorvastatin tablets using different superdisintegrating agents and its IVIVC study", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 7, page no.c54-c76, July-2023, Available :http://www.ijnrd.org/papers/IJNRD2307206.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2307206 Registration ID: 201469 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: c54-c76 Country: Bhaktapur, Bagmati, Nepal Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2307206 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2307206 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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