SUSTAINED RELEASE TABLETS OF GLIPIZIDE: COMPRESSION OF COATED, FORMULATION, DISSOLUTION AND CONVOLUTION

SUSTAINED RELEASE TABLETS OF GLIPIZIDE: COMPRESSION OF COATED, FORMULATION, DISSOLUTION AND CONVOLUTION

Registration ID: IJNRD_201346

Published ID: IJNRD2307145

DOI: Click Here to Get

Tushar Bansod , Shrikant Mahajan , Sachin Dudhe

Glipizide, Lactose, Olibanum resin, Modified release, extended release, Release Kinetics.

The current study's goal was to create a sustained release (SR) tablet formulation of glipizide by combining two hydrophobic polymers with two naturally occurring hydrophilic gum resins. The preparation of several batches of glipizide sustained release tablets moist granulation with lactose and dicalcium phosphate as diluents. The produced pills were assessed based on a number of factors. The commercial Glynase XL pills were compared with the results of an in vitro drug release research. An ideal formulation (SR F3) that contains olibanum resin and lactose as a diluent was discovered to have dissolving profiles that were comparable to those of the reference product. The Korsmeyer and Peppas model provided the best explanation for the kinetics of drug release, and a non-fickian diffusion mechanism was used to release the medication from these tablets. In conclusion, an SR formulation of Glipizide might be created using lactose as a diluent and olibanum resin as a matrix forming that regulates rate.

Published Paper   E-Certificate

"SUSTAINED RELEASE TABLETS OF GLIPIZIDE: COMPRESSION OF COATED, FORMULATION, DISSOLUTION AND CONVOLUTION", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 7, page no.b405-b416, July-2023, Available :https://ijnrd.org/papers/IJNRD2307145.pdf

Volume 8 Issue 7, July-2023

Pages : b405-b416

Paper Reg. ID: IJNRD_201346

Published Paper Id: IJNRD2307145

Downloads: 000121120

Research Area: Pharmacy

Country: Ahmednagar, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2307145.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2307145

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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