SPLEEN-CXCL10-EXPRESSION OF Plasmodium berghei ANKA-INFECTED-SWISS MICE TREATED WITH Annona muricata

Registration ID: IJNRD_200923

Published ID: IJNRD2307087

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Kis Djamiatun

CXCL10, Annona muricata, Plasmodium berghei ANKA

Severe malaria (SM) including cerebral malaria (CM) contributes in high-number of fatal-cases. Brain-T-helper-(Th)1-cells contribute in developing CM, while spleen-Th1-cells control the acute erythrocytic stage of Plasmodium-infection. Th1-cells is attracted by chemokines such as CXCL10. Experimental CM study using Plasmodium berghei ANKA (PbA) showed that treatment which reduces CXCL10 production associated with reducing systemic and brain inflammation, and subsequent increase survival. Aim of this study was to determine the effect of the ethanolic Annona muricata leaf extract (AME) toward spleen-CXCL10-expression of PbA-infected-Swiss-mice during SM. A randomized post-test-only-control-group-design was performed in this study. Thirty-six Swiss-mice were divided into 6 groups. C(-) group was control healthy mice, and C (+) was inoculated with 107 PbA. X1 and X2 group were healthy mice and received AME 100 and 150 mg/kg BW/day, respectively. X3 and X4 group were inoculated with PbA and treated with one of dose studied. The mice were all terminated at day 7 infection when SM occurred. Parasitemia percentage were not different among the infected groups. Results of Kruskal-Wallis-test showed a significant difference among the studied groups (p = 0.022). Mann-Whitney-U-test showed that the expression of the C(+) group had no significant difference than the C (-) group (p=0.054), however those of the PbA-infected X3 and X4-groups were significantly higher than the C(-) group (p = 0.014 and p = 0.009, respectively). The C(+) group expresses CXCL10 comparable to X3 (p = 0.391) and X4 (p = 0.461). The comparable expression was also found between the X3 and X4 groups (p = 0.537). The conclusion is that the use of ethanolic extracted Annona muricata leaves increases spleen-CXCL10-expression above normal during SM. The boosting of splenic CXCL10 expression of the Annona muricata intervention, has no contribution at the severity of malaria infection.

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Kis Djamiatun (July-2023). SPLEEN-CXCL10-EXPRESSION OF Plasmodium berghei ANKA-INFECTED-SWISS MICE TREATED WITH Annona muricata. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(7), a719-a723. https://ijnrd.org/papers/IJNRD2307087.pdf

Volume 8 Issue 7, July-2023

Pages : a719-a723

Paper Reg. ID: IJNRD_200923

Published Paper Id: IJNRD2307087

Research Area: Medical Science

Author Type: Foreign Author

Country: Kota Semarang, Jawa Tengah, Indonesia

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