Formulation and Evaluation of Pharmacosomal Drug Delivery System Of Metformin

Registration ID: IJNRD_200541

Published ID: IJNRD2306633

DOI: Click Here to Get

Dr. Sachin Shivling Bhusari , Aarti Raju Popalghat , Dr.Pravin.S.Wakte

Pharmacosomes, Metformin Hal, phosphotidylcholine, formulation optimization, method validation, sustained release, drug delivery, and diabetes management

This research paper presents a comprehensive investigation into the development, validation, and evaluation of phosphotidylcholine-based pharmacosomes for the efficient delivery of Metformin Hal. Pharmacosomes, emerging as vesicular drug delivery systems, offer tremendous potential to overcome the limitations associated with conventional drug formulations. Metformin HCl, a widely prescribed anti-diabetic drug, often faces challenges in solubility and bioavailability. By utilizing phosphotidylcholine as the primary phospholipid, this study aims to optimize the formulation method, validate its robustness, and evaluate the performance and characteristics of the developed pharmacosomes. Through meticulous selection of phosphotidylcholine and complementary recipients, the formulation parameters, including the drug-to-lipid ratio and lipid-to-surfactant ratio, were optimized to achieve superior drug entrapment efficiency and enhanced stability. Various techniques such as thin-film hydration and solvent evaporation were employed for pharmacosomes preparation, yielding well-defined structures characterized by their size, morphology, and zeta potential. The developed method was subjected to rigorous validation according to regulatory guidelines, including specificity, linearity, precision, accuracy, and robustness assessments. The limit of detection (LOD) and limit of quantification (LOQ) were determined, ensuring sensitivity for future pharmacokinetic studies. Statistical analysis of the validation data confirmed the reliability and reproducibility of the method. Physicochemical characterization revealed the favourable attributes of the phosphotidylcholine-based pharmacosomes, including a narrow particle size distribution, optimal surface charge, and improved drug loading efficiency. Furthermore, the drug release kinetics demonstrated sustained and controlled release profiles, indicating the potential for prolonged therapeutic effects. The stability assessment, encompassing both physical and chemical stability studies, confirmed the long-term viability of the pharmacosomes. In vitro and/or in vivo evaluation of pharmacodynamic and pharmacokinetic parameters further demonstrated the enhanced performance of the phosphotidylcholine-based pharmacosomes in comparison to conventional formulations. This research establishes phosphotidylcholine-based pharmacosomes as a promising and efficient strategy for delivering Metformin Hal. The findings provide valuable insights into the formulation and application of pharmacosomes, highlighting their potential for improving therapeutic outcomes in diabetes management.

Published Paper   E-Certificate

Dr. Sachin Shivling Bhusari, Aarti Raju Popalghat, & Dr.Pravin.S.Wakte (June-2023). Formulation and Evaluation of Pharmacosomal Drug Delivery System Of Metformin. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(6), g279-g302. https://ijnrd.org/papers/IJNRD2306633.pdf

Volume 8 Issue 6, June-2023

Pages : g279-g302

Paper Reg. ID: IJNRD_200541

Published Paper Id: IJNRD2306633

Downloads: 000121989

Research Area: Pharmacy

Country: Aurangabad, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2306633.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2306633

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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