Paper Title
Formulation and Evaluation of Pharmacosomal Drug Delivery System Of Metformin
Article Identifiers
Registration ID: IJNRD_200541
Published ID: IJNRD2306633
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Keywords
Pharmacosomes, Metformin Hal, phosphotidylcholine, formulation optimization, method validation, sustained release, drug delivery, and diabetes management
Abstract
This research paper presents a comprehensive investigation into the development, validation, and evaluation of phosphotidylcholine-based pharmacosomes for the efficient delivery of Metformin Hal. Pharmacosomes, emerging as vesicular drug delivery systems, offer tremendous potential to overcome the limitations associated with conventional drug formulations. Metformin HCl, a widely prescribed anti-diabetic drug, often faces challenges in solubility and bioavailability. By utilizing phosphotidylcholine as the primary phospholipid, this study aims to optimize the formulation method, validate its robustness, and evaluate the performance and characteristics of the developed pharmacosomes. Through meticulous selection of phosphotidylcholine and complementary recipients, the formulation parameters, including the drug-to-lipid ratio and lipid-to-surfactant ratio, were optimized to achieve superior drug entrapment efficiency and enhanced stability. Various techniques such as thin-film hydration and solvent evaporation were employed for pharmacosomes preparation, yielding well-defined structures characterized by their size, morphology, and zeta potential. The developed method was subjected to rigorous validation according to regulatory guidelines, including specificity, linearity, precision, accuracy, and robustness assessments. The limit of detection (LOD) and limit of quantification (LOQ) were determined, ensuring sensitivity for future pharmacokinetic studies. Statistical analysis of the validation data confirmed the reliability and reproducibility of the method. Physicochemical characterization revealed the favourable attributes of the phosphotidylcholine-based pharmacosomes, including a narrow particle size distribution, optimal surface charge, and improved drug loading efficiency. Furthermore, the drug release kinetics demonstrated sustained and controlled release profiles, indicating the potential for prolonged therapeutic effects. The stability assessment, encompassing both physical and chemical stability studies, confirmed the long-term viability of the pharmacosomes. In vitro and/or in vivo evaluation of pharmacodynamic and pharmacokinetic parameters further demonstrated the enhanced performance of the phosphotidylcholine-based pharmacosomes in comparison to conventional formulations. This research establishes phosphotidylcholine-based pharmacosomes as a promising and efficient strategy for delivering Metformin Hal. The findings provide valuable insights into the formulation and application of pharmacosomes, highlighting their potential for improving therapeutic outcomes in diabetes management.
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How To Cite (APA)
Dr. Sachin Shivling Bhusari, Aarti Raju Popalghat, & Dr.Pravin.S.Wakte (June-2023). Formulation and Evaluation of Pharmacosomal Drug Delivery System Of Metformin. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(6), g279-g302. https://ijnrd.org/papers/IJNRD2306633.pdf
Issue
Volume 8 Issue 6, June-2023
Pages : g279-g302
Other Publication Details
Paper Reg. ID: IJNRD_200541
Published Paper Id: IJNRD2306633
Research Area: Pharmacy
Author Type: Indian Author
Country: Aurangabad, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2306633.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2306633
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