FORMULATION AND EVALUATION OF GLIPIZIDE SUSTAINED RELEASE TABLETS

Registration ID: IJNRD_200461

Published ID: IJNRD2306613

DOI: Click Here to Get

Suraj M. Gholap , Nitin D. Dhonde , Shubham D. Lambe , Amol B. Chavan

Glipizide, Lactose, Olibanum resin, Modified release, extended release, Release Kinetics

The current study's goal was to create a sustained release (SR) tablet formulation of glipizide by combining two hydrophobic polymers with two naturally occurring hydrophilic gum resins. The preparation of several batches of Glipizide sustained release tablets moist granulation with lactose and dicalcium phosphate as diluents. The produced pills were assessed based on a number of factors. The commercial Glynase XL pills were compared with the results of an in vitro drug release research. An ideal formulation (SR F3) that contains olibanum resin and lactose as a diluent was discovered to have dissolving profiles that were comparable to those of the reference product. The Korsmeyer and Peppas model provided the best explanation for the kinetics of drug release, and a non-fickian diffusion mechanism was used to release the medication from these tablets. In conclusion, an SR formulation of Glipizide might be created using lactose as a diluent and olibanum resin as a matrix forming that regulates rate.

Published Paper   E-Certificate

Suraj M. Gholap, Nitin D. Dhonde, Shubham D. Lambe, & Amol B. Chavan (June-2023). FORMULATION AND EVALUATION OF GLIPIZIDE SUSTAINED RELEASE TABLETS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(6), g110-g121. https://ijnrd.org/papers/IJNRD2306613.pdf

Volume 8 Issue 6, June-2023

Pages : g110-g121

Paper Reg. ID: IJNRD_200461

Published Paper Id: IJNRD2306613

Downloads: 000121974

Research Area: Pharmacy

Country: Ahmednagar, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2306613.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2306613

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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