Paper Title
Recent Developments in Tumor Targeting Drug Delivery Systems: A Comprehensive Review
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Registration ID: IJNRD_200283
Published ID: IJNRD2306500
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Keywords
tumor targeting, drug delivery systems, passive targeting, active targeting, stimuli-responsive, nanoparticle-based, nucleic acid delivery, lipid nanoparticles, polymer-based nanoparticles, metal-based nanoparticles, exosomes, antibody-drug conjugates, peptide-based, characterization techniques, biocompatibility, safety assessment.
Abstract
Tumor targeting drug delivery systems have gained significant attention as a promising approach to improve the efficacy and safety of cancer therapies. This comprehensive review highlights recent developments in this field, encompassing various strategies and advancements. Passive targeting strategies exploit the enhanced permeability and retention effect and size-based targeting for preferential accumulation of drug-loaded carriers in tumors. Active targeting strategies utilize ligand-mediated, antibody-mediated, aptamer-mediated, and nanobody-based approaches to enhance specificity by selectively binding to tumor-specific receptors. Stimuli-responsive targeting strategies, including pH-responsive, enzyme-responsive, and temperature-responsive systems, enable triggered drug release within the tumor microenvironment. Nanoparticle-based drug delivery systems have seen remarkable progress, particularly lipid-based, polymer-based, and metal-based nanoparticles, offering improved drug encapsulation, controlled release, and enhanced targeting capabilities. Notably, nanocarriers designed for nucleic acid delivery, such as lipid nanoparticles for RNA delivery and polymeric nanoparticles for gene delivery, hold great promise for gene-based cancer therapies. .This comprehensive review provides an overview of the recent developments in this field, focusing on various strategies and technologies employed for efficient and specific drug delivery to tumor sites.
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How To Cite (APA)
Udipta paul , Dhruba kishore paul , & Mouly mitra (June-2023). Recent Developments in Tumor Targeting Drug Delivery Systems: A Comprehensive Review. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(6), e823-e831. https://ijnrd.org/papers/IJNRD2306500.pdf
Issue
Volume 8 Issue 6, June-2023
Pages : e823-e831
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Paper Reg. ID: IJNRD_200283
Published Paper Id: IJNRD2306500
Research Area: Pharmacy
Author Type: Indian Author
Country: Habra, , West Bengal , India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2306500.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2306500
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