Paper Title
Review on Griseofulvin as Antifungal agnet
Article Identifiers
Authors
Mr. Nilesh Kothare , Miss. Pawar Madhuri , Miss. Khandagale Shital , Dr. Kamble Hemant , Mr. Waghmare Santosh
Keywords
drug repurposing, dermatophytic fungal, gsf gene cluster, polyketide molecule, SARS-CoV-2, spindle microtubule, and griseofulvin derivatives.
Abstract
In India, dermatophyte infections have recently undergone unheard-of alterations.The effectiveness of the few primary oral antifungal medicines is not compared in any clinical studies. Dermatophytosis is treated with griseofulvin, a fungistatic antifungal drug. The dermatophytes that are frequently recognised include fungal species including Trichophyton mentagrophytes, Fusarium oxysporum, Microsporumgypseum, and Epidermophyton floccosum.may improve vascular relaxation, enhance ACE2 activity, and raise capillary blood flow.Additionally, a molecular docking analysis revealed that the receptor-binding domain (RBD) of the spike protein may prevent SARS-CoV-2 entry and viral replication when used in combination with variants of griseofulvin and its major protease, RNA-dependent RNA polymerase (RdRp), and other proteins.
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How To Cite (APA)
Mr. Nilesh Kothare, Miss. Pawar Madhuri, Miss. Khandagale Shital, Dr. Kamble Hemant, & Mr. Waghmare Santosh (June-2023). Review on Griseofulvin as Antifungal agnet. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(6), e41-e50. https://ijnrd.org/papers/IJNRD2306406.pdf
Issue
Volume 8 Issue 6, June-2023
Pages : e41-e50
Other Publication Details
Paper Reg. ID: IJNRD_199837
Published Paper Id: IJNRD2306406
Downloads: 000121195
Research Area: Pharmacy
Country: Ahmadnagar (M Corp.), Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2306406.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2306406
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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