Review on Griseofulvin as Antifungal agnet

Registration ID: IJNRD_199837

Published ID: IJNRD2306406

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Mr. Nilesh Kothare, Miss. Pawar Madhuri, Miss. Khandagale Shital, Dr. Kamble Hemant, Mr. Waghmare Santosh

drug repurposing, dermatophytic fungal, gsf gene cluster, polyketide molecule, SARS-CoV-2, spindle microtubule, and griseofulvin derivatives.

In India, dermatophyte infections have recently undergone unheard-of alterations.The effectiveness of the few primary oral antifungal medicines is not compared in any clinical studies. Dermatophytosis is treated with griseofulvin, a fungistatic antifungal drug. The dermatophytes that are frequently recognised include fungal species including Trichophyton mentagrophytes, Fusarium oxysporum, Microsporumgypseum, and Epidermophyton floccosum.may improve vascular relaxation, enhance ACE2 activity, and raise capillary blood flow.Additionally, a molecular docking analysis revealed that the receptor-binding domain (RBD) of the spike protein may prevent SARS-CoV-2 entry and viral replication when used in combination with variants of griseofulvin and its major protease, RNA-dependent RNA polymerase (RdRp), and other proteins.

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Mr. Nilesh Kothare, Miss. Pawar Madhuri, Miss. Khandagale Shital, Dr. Kamble Hemant, & Mr. Waghmare Santosh (June-2023). Review on Griseofulvin as Antifungal agnet. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(6), e41-e50. https://ijnrd.org/papers/IJNRD2306406.pdf

Volume 8 Issue 6, June-2023

Pages : e41-e50

Paper Reg. ID: IJNRD_199837

Published Paper Id: IJNRD2306406

Downloads: 000121993

Research Area: Pharmacy

Author Type: Indian Author

Country: Ahmadnagar (M Corp.), Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2306406.pdf

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