Paper Title
Formulation Design and Optimization of Fast Disintegrating Tablets of Atorvastatin Calcium Using Solid Dispersion Technique
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Registration ID: IJNRD_199292
Published ID: IJNRD2306376
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Keywords
Atorvastatin calcium, polyvinyl pyrrolidone K30, solid dispersion, kneading method, fast disintegrating tablets, factorial design
Abstract
The purpose of the present investigation was to increase the solubility and dissolution rate of atorvastatin calcium by the preparation of its solid dispersion with polyvinyl pyrrolidone K30 (PVP K30) using kneading method. Drug polymer interactions were investigated using differential scanning calorimetry (DSC), x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). For the preparation of atorvastatin calcium fast disintegrating tablets, its 1:6 solid dispersion with PVP K30 was used with various natural and synthetic superdisintegrants. In an attempt to construct a statistical model for the prediction of wetting time, disintegration time and percentage dissolution, a 32 full factorial design was used to optimize the influence of the amounts of superdisintegrants. The obtained results showed that dispersion of the drug in the polymer considerably enhanced the dissolution rate. The drug-to-carrier ratio was the controlling factor for dissolution improvement. FTIR spectra revealed no chemical incompatibility between the drug and PVP K30. As indicated from XRD and DSC data, atorvastatin calcium was in the amorphous form, which explains the better dissolution rate of the drug from its solid dispersions. Concerning the optimization study, the regression analysis revealed that an optimum concentration of SSG and crospovidone are required for obtaining fast disintegrating tablets. In conclusion, this investigation demonstrated the potential of experimental design in understanding the effect of the formulation variables on the quality of fast disintegrating tablets containing solid dispersion of a hydrophobic drug.
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How To Cite (APA)
Mr. Manish Kumar Chaudhary, Mr. Kashif Hussain, Dr. Yogita Tyagi, & Mr. Praveen Kumar Ashok (June-2023). Formulation Design and Optimization of Fast Disintegrating Tablets of Atorvastatin Calcium Using Solid Dispersion Technique. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(6), d735-d745. https://ijnrd.org/papers/IJNRD2306376.pdf
Issue
Volume 8 Issue 6, June-2023
Pages : d735-d745
Other Publication Details
Paper Reg. ID: IJNRD_199292
Published Paper Id: IJNRD2306376
Research Area: Pharmacy
Author Type: Indian Author
Country: Bangalore, Karnataka, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2306376.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2306376
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