Formulation And Estimation Of Aceclofenac Topical Emulgels

Registration ID: IJNRD_197920

Published ID: IJNRD2305919

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Kautkar Avinash Bapurao , Mr.Raut A.N , Dr.Santosh Jain , Mangalpawar Mukund

Abstract—Aceclofenac is a new non-steroidal anti-inflammatory drug (NSAIDs) having a remarkable analgesic, anti-inflammatory and anti-pyretic potential. Chemically it is named as (2-[(2,6- dichlorophenyl) amine] or phenylacetoxya acetic acid. So, this research was based on designing and formulation of topical aceclofenac emulgel with different and suitable gelling agents with different ratio of mixing and evaluation of same by following standard parameters. Firstly, preformulation studies were done to make sure the raw materials are of quality grade. The different emulgels were formulated as Aceclofenac (API), API + Span 20, API + Tween 20, API + Carbopol 934, API + HPMC K4 M, API + Liq. Paraffin, API +Propylene Glycol, API + Menthol and API + Methyl Paraben. The emulgels were evaluated for various parameters such as physical tests, rheological properties, estimation of pH, skin irritation test, in-vitro drug release and swelling index. The different formulations of Emulgels were evaluated for their rheological properties.Formulation no. 1, 2 and 3 were analyzed at RPM 0.2. At shear stress of 165.8 for F1demonstrated the viscosity of 13950. For F2 at shear stress 170.6 the viscosity was noted as 15526. At last, for F3 at shear stress of 170.6 the viscosity was found as 14526. The in-vitrodrug release study was recorded from 0.5 hr to 8 hrs. The amount of drug was found to be 1.32mg, 1.31mg and 1.31mg in 1 gm of Emulgel formulation no. 1, 2 and 3. This research comes under the New Drug Delivery System (NDDS) that enhances the new approach infrequent dermal delivery of loaded Aceclofenac topical emulgel.

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Kautkar Avinash Bapurao, Mr.Raut A.N, Dr.Santosh Jain, & Mangalpawar Mukund (May-2023). Formulation And Estimation Of Aceclofenac Topical Emulgels . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), j32-j37. https://ijnrd.org/papers/IJNRD2305919.pdf

Volume 8 Issue 5, May-2023

Pages : j32-j37

Paper Reg. ID: IJNRD_197920

Published Paper Id: IJNRD2305919

Downloads: 000121990

Research Area: Pharmacy

Country: NANDED, MAHARASHTRA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2305919.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305919

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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