Paper Title
DEVLOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTIFICATION OF THIOCOLCHICOSIDE AND DCLOFENAC DIETHYLAMINE IN PRESENCE OF ACTIVE EXCIPIENTS FROM THEIR COMBINED SEMISOLID TOPICAL PREPARATION
Article Identifiers
Authors
LOHIYA NISHABEN NARESHBHAI , MR KETAN RATHOD , DR CHAITANYA BHATT , DR. VANITA MARVANIYA
Keywords
Thiocolchicoside, Diclofenac Diethylamine, RP-HPLC Method
Abstract
A simple, accurate, precise, specific reverse phase high performace liquid chromatography method was developed and validated for quantification of Thiocolchicoside and Diclofenac Diethylamine in combined pharmaceutical formulation (gel). The approach was validated for Thiocolchicoside and Diclofenac Diethylamine using ICH recommendations over a range of 1-5 µg/mL and 9-45 µg/mL for Thiocolchicoside and Diclofenac Diethylamine respectively. An analytical column HYPERSIL ODS C18, 250 mm*4.6 mm was utilized. At a flow rate of 1.0 ml/min, the mobile phase was Acetonitrile and 0.025M potassium hydrogen phosphate buffer in a (50:50 v/v) ratio. The elution was examined using a UV detector with a detection wavelength of 254 nm. The retention times for Thiocolchicoside and Diclofenac Diethylamine are 4.3 minutes and 9.8 minutes, respectively. The percentage recoveries for Thiocolchicoside and Diclofenac Diethylamine were 99.00-101.5 % and 99.11-100.22 %, respectively. The RSD values are not greater than 2%.
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How To Cite (APA)
LOHIYA NISHABEN NARESHBHAI, MR KETAN RATHOD, DR CHAITANYA BHATT, & DR. VANITA MARVANIYA (May-2023). DEVLOPMENT AND VALIDATION OF RP-HPLC METHOD FOR QUANTIFICATION OF THIOCOLCHICOSIDE AND DCLOFENAC DIETHYLAMINE IN PRESENCE OF ACTIVE EXCIPIENTS FROM THEIR COMBINED SEMISOLID TOPICAL PREPARATION. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), h769-h787. https://ijnrd.org/papers/IJNRD2305798.pdf
Issue
Volume 8 Issue 5, May-2023
Pages : h769-h787
Other Publication Details
Paper Reg. ID: IJNRD_197165
Published Paper Id: IJNRD2305798
Downloads: 000121977
Research Area: Pharmacy
Country: AHEMEDABAD, GUJRAT, INDIA
Published Paper PDF: https://ijnrd.org/papers/IJNRD2305798.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305798
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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