Paper Title
FORMULATION AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES OF KETOPROFEN USING TAMARIND KERNAL POWDER AS MUCO ADHESIVE POLYMER
Article Identifiers
Authors
SAILAJA RONGALI , Jagadeesh panda , G.Kusuma , V.Keerthana G. Rohini , V.Geethika sai
Keywords
Tansdermal patch, ketoprofen, Ethyl cellulose, tamarind kernel powder, Franz Diffusion cell and controlled release
Abstract
AIM: The aim of the work is to formulate and evaluate the transdermal patches of ketoprofen using different combinations of polymers and plasticizers. OBJECTIVE: •. Transdermal patches of ketoprofen were prepared to sustain the release and patient compliance. Different formulations were prepared by using different combinations of the polymers like HPMC E5 LV: Eudragit E 100. (1:1,1:2,1:3) and Ethyl cellulose and PVP ratio (1:1,1:2,1:3)by solvent casting method. Tamarind kernel powder is used as a mucoadhesive polymer. The prepared formulations were evaluated for various parameters like moisture content, moisture uptake, folding endurance , percentage drug content , In-vitro permeation using Franz diffusion cell, drug-excipient compatibility by FTIR studies. The diffusion data was fitted into various kinetic models (zero order, first order, Higuchi and Korsmeyer peppas model). The formulation containing the combination of Ethyl cellulose and PVP at a ratio of 1:3 using PEG 4000 as plasticiser was considered optimum batch and showed the drug release up to 8hrs ,91.78% and more similar to the marketed ketoprofen patch (30mg) and similarity factor was calculated as f2=60.78.
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How To Cite (APA)
SAILAJA RONGALI, Jagadeesh panda, G.Kusuma, V.Keerthana G. Rohini, & V.Geethika sai (May-2023). FORMULATION AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES OF KETOPROFEN USING TAMARIND KERNAL POWDER AS MUCO ADHESIVE POLYMER. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), h510-h517. https://ijnrd.org/papers/IJNRD2305769.pdf
Issue
Volume 8 Issue 5, May-2023
Pages : h510-h517
Other Publication Details
Paper Reg. ID: IJNRD_196861
Published Paper Id: IJNRD2305769
Downloads: 000121981
Research Area: Pharmacy
Country: visakhapatnam, Andhra Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2305769.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305769
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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