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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | A REVIEW ON THE STAGES OF DRUG DISCOVERY & DRUG DEVELOPMENT PROCESS |
| Authors Name: | Mr. Prashant D. Rathod , Mr. Mukesh M. Nikhade , Mr. Nayan D. Chaudhari , Mr. Gajanan V. Jadhao , Mr. Avinash B. Gore |
| Download E-Certificate: | Download |
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IJNRD_196454
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| Published Paper Id: | IJNRD2305645 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | |
| Abstract: | Drug discovery is the process of identifying a compound therapeutically useful in the treatment and cure of disease and therapeutic efficacy tests. Once a compound proves its worth in these studies, it begins the drug development process before clinical trials. It takes about 12 to 15 years from discovery to an approved drug and requires an investment of about $1 billion. On average of the million molecules are screened, but they only one is explored in the late stages of clinical trials and is finally available to patients. This article provides a brief outline of the processes involved in the discovery and development of new drugs. This testing is done on cells (in vitro) and animals (in vivo) to study metabolism and to produce a product that is safe and meets all regulatory requirements. It may be a protein receptor that is related to a disease state, so it is important to know how the disease occurs at the molecular, cellular and genetic level. Once a target is identified, the next step is how the target plays a role in the disease process. The development and discovery of a new drug to treat a disease is expensive and requires up to 14 years of research and testing. Proper procedure requires a step-by-step approach along with well documentation. The work usually begins with target identification and validation. Optimization, lead compound discovery, and preclinical animal testing are the various stages that must be followed by clinical trials and evaluation of drug candidates in humans. This review article will cover the key concepts of drug discovery, drug development and the clinical phases of drug discovery. |
| Keywords: | Lead optimization, clinical phase trial, target validation, target identification, Investigation new drug |
| Cite Article: | "A REVIEW ON THE STAGES OF DRUG DISCOVERY & DRUG DEVELOPMENT PROCESS", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.g368-g375, May-2023, Available :http://www.ijnrd.org/papers/IJNRD2305645.pdf |
| Downloads: | 000118755 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2305645 Registration ID: 196454 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: g368-g375 Country: Yavatmal, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2305645 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2305645 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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