Molecular docking study of Novel Chalcone derivatives Towards PDB: 1CX2

Registration ID: IJNRD_195891

Published ID: IJNRD2305490

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Jayshree B. Naik, Shubham A. Cheke, Vishal P. Kakde

Molecular docking ,Anti-inflammatory, Auto Dock Tool, COX-2.

Chalcones are the natural phytoconstituents recognized as secondary metabolites of plant, with marked biological significance such as Anti-inflammatory, Antioxidant, Anticancer, and Antimicrobial activity. On the basis of literature we were design Novel chalcone derivatives & were access for anti-inflammatory activity. This research deals with a molecular docking study of newly designed (1-(5- chloro-2-hydoxyphenyl)-3-(3-methylphenyl)propanr-1,3-dione) derivatives was performed by using Auto Dock Tool (V 1.5.7) with PDB Id: 1CX2 for drug protein interaction study. The main objective of molecular docking is to predict the biological activity of given ligand. In above research we done molecular docking study of JBN-1 to JBN-5 towards COX-2 Inhibitor. In this manuscript molecular docking study compound JBN-2 shows better docking score (-9.4) and compound JBN-3 shown moderate docking score (-6.6) compare to standard Celecoxib (-8.3) respectively.

Published Paper   E-Certificate

Jayshree B. Naik, Shubham A. Cheke, & Vishal P. Kakde (May-2023). Molecular docking study of Novel Chalcone derivatives Towards PDB: 1CX2. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), e737-e746. https://ijnrd.org/papers/IJNRD2305490.pdf

Volume 8 Issue 5, May-2023

Pages : e737-e746

Paper Reg. ID: IJNRD_195891

Published Paper Id: IJNRD2305490

Downloads: 000122253

Research Area: Pharmacy

Author Type: Indian Author

Country: Aurangabad, Maharastra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2305490.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305490

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