Paper Title
Molecular docking study of Novel Chalcone derivatives Towards PDB: 1CX2
Article Identifiers
Authors
Jayshree B. Naik , Shubham A. Cheke , Vishal P. Kakde
Keywords
Molecular docking ,Anti-inflammatory, Auto Dock Tool, COX-2.
Abstract
Chalcones are the natural phytoconstituents recognized as secondary metabolites of plant, with marked biological significance such as Anti-inflammatory, Antioxidant, Anticancer, and Antimicrobial activity. On the basis of literature we were design Novel chalcone derivatives & were access for anti-inflammatory activity. This research deals with a molecular docking study of newly designed (1-(5- chloro-2-hydoxyphenyl)-3-(3-methylphenyl)propanr-1,3-dione) derivatives was performed by using Auto Dock Tool (V 1.5.7) with PDB Id: 1CX2 for drug protein interaction study. The main objective of molecular docking is to predict the biological activity of given ligand. In above research we done molecular docking study of JBN-1 to JBN-5 towards COX-2 Inhibitor. In this manuscript molecular docking study compound JBN-2 shows better docking score (-9.4) and compound JBN-3 shown moderate docking score (-6.6) compare to standard Celecoxib (-8.3) respectively.
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How To Cite (APA)
Jayshree B. Naik, Shubham A. Cheke, & Vishal P. Kakde (May-2023). Molecular docking study of Novel Chalcone derivatives Towards PDB: 1CX2. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), e737-e746. https://ijnrd.org/papers/IJNRD2305490.pdf
Issue
Volume 8 Issue 5, May-2023
Pages : e737-e746
Other Publication Details
Paper Reg. ID: IJNRD_195891
Published Paper Id: IJNRD2305490
Downloads: 000121982
Research Area: Pharmacy
Country: Aurangabad, Maharastra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2305490.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305490
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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