Paper Title
Design, characterization and Evaluation of mouth dissolving film (MDF) containing Enalapril maleate.
Article Identifiers
: Keywords
dissolving, release, film, HPMC, disintegration
Abstract
Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking. To avoid such difficulties, film like dosage forms were developed. The aim of this study was to formulate and optimized mouth dissolving film containing Enalapril maleate by 3 level 2 factor full factorial design using design expert® software. Mouth dissolving film was formulated by using solvent casting method. HPMC E15 and sodium starch glycolate concentrations were selected as independent variable. Enalapril maleate containing film of HPMC E15 was optimized by selecting the disintegration time and tensile strength as response which is evaluated by design expert® software. Disintegration time is important constraint for immediate release dosage form. Concentrations of HPMC E15 and sodium starch glycolate affect the disintegration of film and tensile strength. Desirability for Quadratic model was significant compare to other models. About 99.77 % of drug release was obtained from In vitro drug release study and follows korsmeyer peppas model. Films were characterized by using DSC Thickness, tensile strength, folding endurance test and evaluated for their physical and mechanical properties. Stability study of optimized film for two months reveals that formulation was stable for specified time period. From this study it was concluded that disintegration time was directly proportional to concentration of sodium starch glycolate and inversely proportional to concentration of HPMC E15.Concentration of Sodium starch glycolate directly proportional to tensile strength and inversely proportional to disintegration time.
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How To Cite (APA)
Taral Mayur Navnath & Kashid Vivekanand Ankush (May-2023). Design, characterization and Evaluation of mouth dissolving film (MDF) containing Enalapril maleate.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), e717-e730. https://ijnrd.org/papers/IJNRD2305488.pdf
Issue
Volume 8 Issue 5, May-2023
Pages : e717-e730
Other Publication Details
Paper Reg. ID: IJNRD_195932
Published Paper Id: IJNRD2305488
Downloads: 000122257
Research Area: Pharmacy
Author Type: Indian Author
Country: Ahmednagar, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2305488.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305488
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