Design, characterization and Evaluation of mouth dissolving film (MDF) containing Enalapril maleate.

Design, characterization and Evaluation of mouth dissolving film (MDF) containing Enalapril maleate.

Registration ID: IJNRD_195932

Published ID: IJNRD2305488

DOI: Click Here to Get

Taral Mayur Navnath , Kashid Vivekanand Ankush

dissolving, release, film, HPMC, disintegration

Many pediatric and geriatric patients are unwilling to take solid preparations due to fear of choking. To avoid such difficulties, film like dosage forms were developed. The aim of this study was to formulate and optimized mouth dissolving film containing Enalapril maleate by 3 level 2 factor full factorial design using design expert® software. Mouth dissolving film was formulated by using solvent casting method. HPMC E15 and sodium starch glycolate concentrations were selected as independent variable. Enalapril maleate containing film of HPMC E15 was optimized by selecting the disintegration time and tensile strength as response which is evaluated by design expert® software. Disintegration time is important constraint for immediate release dosage form. Concentrations of HPMC E15 and sodium starch glycolate affect the disintegration of film and tensile strength. Desirability for Quadratic model was significant compare to other models. About 99.77 % of drug release was obtained from In vitro drug release study and follows korsmeyer peppas model. Films were characterized by using DSC Thickness, tensile strength, folding endurance test and evaluated for their physical and mechanical properties. Stability study of optimized film for two months reveals that formulation was stable for specified time period. From this study it was concluded that disintegration time was directly proportional to concentration of sodium starch glycolate and inversely proportional to concentration of HPMC E15.Concentration of Sodium starch glycolate directly proportional to tensile strength and inversely proportional to disintegration time.

Published Paper   E-Certificate

"Design, characterization and Evaluation of mouth dissolving film (MDF) containing Enalapril maleate.", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 5, page no.e717-e730, May-2023, Available :https://ijnrd.org/papers/IJNRD2305488.pdf

Volume 8 Issue 5, May-2023

Pages : e717-e730

Paper Reg. ID: IJNRD_195932

Published Paper Id: IJNRD2305488

Downloads: 000121125

Research Area: Pharmacy

Country: Ahmednagar, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2305488.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305488

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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