Formulation development and evaluation of nanoparticles of Anti-diabetic drug by Hot Homogenization technique

Registration ID: IJNRD_195820

Published ID: IJNRD2305486

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Mr. Shubham S. Ingavale , Mr. Sumit S. Chavan , Mr. Vaibhav L. Kharat , Mr. Tushar D. Bhosale , Prof. Vikas B. Wamane

Glimepiride, hot homogenization technique, Nanocapsule, nanopartical, homogenization

Nanostructured lipid carriers of glimepiride (NLC) have been developed for the treatment of type 2 diabetes. The developed NLC consists of Compritol ATO 888 as a solid lipid, medium chain triglycerides as a liquid lipid, and Poloxamer 188 as a surfactant. NLCs were prepared using a hot homogenization method and characterized by FT-IR. All NLCs showed recording efficiency in the range of 78.52 to 90.38%. Both the capture efficiency and the release rate were affected by the lipid concentration. Formulation F5 was considered an optimized formulation based on particle size and percentage of drug release. The zeta potential value indicated good stability of the particles. The optimized formulation showed no physical/chemical changes when exposed to accelerated stability conditions. It was concluded that the developed NLC is a potential approach for controlled medication that can reduce dosing frequency and improve patient compliance.

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Mr. Shubham S. Ingavale, Mr. Sumit S. Chavan, Mr. Vaibhav L. Kharat, Mr. Tushar D. Bhosale, & Prof. Vikas B. Wamane (May-2023). Formulation development and evaluation of nanoparticles of Anti-diabetic drug by Hot Homogenization technique. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), e694-e709. https://ijnrd.org/papers/IJNRD2305486.pdf

Volume 8 Issue 5, May-2023

Pages : e694-e709

Paper Reg. ID: IJNRD_195820

Published Paper Id: IJNRD2305486

Downloads: 000121976

Research Area: Pharmacy

Country: Shrirampur, maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2305486.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305486

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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