The Synthesis of Medicinally Important Pharma Molecules from Carbohydrates Building Blocks

Registration ID: IJNRD_195569

Published ID: IJNRD2305414

DOI: http://doi.one/10.1729/Journal.34244

Dr Mukesh Chander , Dr Rajiv Kumar , Dr Rajan Salwan

Carbohydrates, Glycoconjugates, Glycals, Fischer – Zach synthesis, NMR

The carbohydrate molecules forms a variety of natural products named “glycoconjugates – key components of different biological processes”. The challenge lies in preparation of bulk quantities of these organics for industrial application and processes. The monosaccharide as raw material to synthesize glycoconjugates are available in large quantities so as to oligomerise these monosaccharides.The chiral nature of monosaccharide has made them suitable to use as starting material also for the synthesis of compounds other than glycoconjugates. Glycal a cyclic enol ether derivatives of sugars can be formed as pyranose (six-membered) or furanose (five-membered) rings, depending on the monosaccharide used as a starting material to synthesize the glycal which can be transformed to an exo-glycal. More recently, glycals have also been shown to be excellent starting substrates for library development and preparation of exo - glycals. The Fischer–Zach method has been one of the most popular methods for synthesizing glycals. It has been suggested that heterolytic cleavage of the carbon–halogen bond occurs under these acidic conditions ,initially to give an anomeric carbocation that, after taking two electrons from the zinc atom, generates a transient carbanion that evolves through the splitting off of an acetate anion. In present study we have investigated the role of other reducing agents in this transformation with glycosyl halides include sodium and potassium metal, sodium naphthalide, zinc/silver graphite, aluminum amalgam, SmI2, potassium graphite ,lithium/ammonia, chromium(II), zinc/base, cobalt(II), and titanium(III). A glucal derivative has also been prepared by introduction of a halogen atom at C-2, followed by a reductive elimination reaction in the opposite sense.

Published Paper   E-Certificate

Dr Mukesh Chander, Dr Rajiv Kumar, & Dr Rajan Salwan (May-2023). The Synthesis of Medicinally Important Pharma Molecules from Carbohydrates Building Blocks. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(5), e133-e148. http://doi.one/10.1729/Journal.34244

Volume 8 Issue 5, May-2023

Pages : e133-e148

Paper Reg. ID: IJNRD_195569

Published Paper Id: IJNRD2305414

Downloads: 000121986

Research Area: Life Sciences 

Country: Amritsar, Punjab, India

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Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305414

Crossref DOI: http://doi.one/10.1729/Journal.34244

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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